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Uncultured bacterium

ABSTRACT: Population census of myxobacteria in a soil niche

PROVIDER: PRJNA89421 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR420843.fastq.gz	Fastqsanger.gz
	SRR420845.fastq.gz	Fastqsanger.gz
	SRR420846.fastq.gz	Fastqsanger.gz
	SRR420847.fastq.gz	Fastqsanger.gz

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A new antibiotic from an uncultured bacterium binds to an immutable target

Project description:Antimicrobial resistance is a leading mortality factor worldwide. Here we report the discovery of clovibactin, a new antibiotic, isolated from uncultured soil bacteria. Clovibactin efficiently kills drug-resistant Gram-positivebacterial pathogens without detectable resistance. Using biochemical assays,solid-state NMR, and atomic force microscopy, we dissect its mode of action. Clovibactin blocks cell wall synthesis by targeting pyrophosphate of multiple essential peptidoglycan precursors (C55PP, Lipid II, LipidWTA). Clovibactin uses anunusual hydrophobic interface to tightly wrap aroundpyrophosphate, butbypasses the variable structural elements of precursors, accounting for the lack of resistance. Selective and efficient target binding is achieved by the sequestration of precursors into supramolecular fibrils that only form on bacterial membranes that contain lipid-anchored pyrophosphate groups.Uncultured bacteria offer a rich reservoir of antibiotics with new mechanisms of action that could replenish the antimicrobial discovery pipeline.

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Deletion of an sRNA primes development in a multicellular bacterium

Project description:Small non-coding RNAs (sRNAs) are essential in regulating gene expression during many biological processes. In myxobacteria, the gene pxr encodes for an sRNA known to block the activation of fruiting body development, an aggregative multicellular process triggered by starvation. However, a comprehensive list of potential targets of Pxr and whether these are indeed associated with development still needs to be determined. Here, we profiled the transcriptome of vegetative cells lacking pxr and obtained a list of genes affected by the absence of this sRNA. Interestingly, we found that the absence of pxr influences the expression of genes associated with metabolic processes in general. However, our experiment strengthened the association between pxr and aggregative development with more than half of the differentially expressed genes linked to fruiting body formation. By ours with previously published data, we identified critical factors of myxobacteria aggregative multicellularity as potential pxr targets combining. Moreover, our study supports the existence of additional not yet described genes relevant to fruiting body development that Pxr possibly controls. Among them, we identify pxrA, a novel gene encoding for a GNAT-acetyltransferase that we showed to be important to fruiting body development and associated with pxr expression. We additionally found that the altered expression of developmental genes caused by the absence of pxr correlates with a dramatic variation in the temporal dynamics of development, thus suggesting an important role of this sRNA in myxobacteria ecology.

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Project description:Natural gas well equipment bacterial population Targeted Locus (Loci)

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