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Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness: CUT&Tag

ABSTRACT: Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness: CUT&Tag

PROVIDER: PRJNA894524 | ENA |

REPOSITORIES: ENA

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Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness

Project description:Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness

| PRJNA894521 | ENA

Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness

Project description:The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisingly found that prolonged acid exposure reprogrammed T cell intracellular metabolism and mitochondrial fitness, and preserved T cell stemness. Elevated extracellular-acidosis impaired methionine uptake and metabolism via downregulating SLC7A5, therefore altering H3K27me3 deposition at the promoters of crucial T cell stemness genes. These changes promoted the maintenance of a “stem-like memory” state and improved long-term in vivo persistence and anti-tumor efficacy. Our findings not only reveal the unexpected roles of extracellular-acidosis in the maintenance of stem-like properties of T cells, but also advance our understanding of the direct involvement of methionine metabolism in T cell stemness.

2023-01-17 | MTBLS6661 | MetaboLights

Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness: RNA-seq

2022-12-05 | GSE216622 | GEO

Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness: CUT&Tag

2022-12-05 | GSE216621 | GEO

Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness: RNA-seq

Project description:Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness: RNA-seq

| PRJNA894525 | ENA

Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness (RNA-seq of sodium lactate samples)

2022-12-05 | GSE219257 | GEO

Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness (RNA-seq of sodium lactate samples)

Project description:Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness (RNA-seq of sodium lactate samples)

| PRJNA907811 | ENA

Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-12-05 | GSE216623 | GEO

PRC2 preserves cellular plasticity and restricts intestinal secretory lineage commitment

Project description:PRC2 preserves cellular plasticity and restricts intestinal secretory lineage commitment

| PRJNA319238 | ENA

Lactic acidosis triggers starvation response with distinct metabolic profiles

Project description:[1] Lactic acidosis time course: MCF7 cells were exposed to lactic acidosis for different length of time. We used microarrays to examine the genomic programs of cells incubated under lactic acidosis for different length of time [2] Metabolic profiling: MCF7 cells were exposed to control condition, 25mM lactic acidosis, glucose deprivation (zero glucose) and hypoxia (1% oxygen level). [3] Mouse study: Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. Wild-type mouse embryo fibroblasts (MEFs) and TXNIP-null MEFs were exposed to Ctrl versus lactic acidosis conditions for 24hrs and the RNAs from cells were extracted with MiRVana kit (Ambion) and applied to Affymetrix 430A mouse chips We used microarrays to examine the genomic programs of cells incubated under different microenvironmental stresses. [1] Lactic acidosis time course: MCF7 cells were exposed to lactic acidosis for 1, 4, 12 and 24 hours. [2] Metabolic profiling: MCF7 cells were exposed to lactic acidosis, glucose deprivation and hypoxia for 4hours. [3] wild-type mouse embryo fibroblasts (MEFs) and TXNIP-null MEFs were exposed to Ctrl versus lactic acidosis conditions for 24hrs.

2010-09-27 | E-GEOD-19123 | biostudies-arrayexpress

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