Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome analysis of tumors isolated from ovarian cancer tumor bearing mice treated with Sindbis Virus vectors and untreated controls

ABSTRACT: Transcriptome analysis of tumors isolated from ovarian cancer tumor bearing mice treated with Sindbis Virus vectors and untreated controls

PROVIDER: PRJNA895099 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptome analysis of tumors isolated from ovarian cancer tumor bearing mice treated with Sindbis Virus vectors and untreated controls

Project description:Gene expression analysis of tumors isolated from mice after they received treatments with Sindbis Virus vectors for 1 week. The hypothesis tested changes in the transcriptome profiles of tumors isolated from Sindbis virus vectors treated and untreated mice. Expression profiling by high throughput sequencing of MOSEC.Fluc.p11 tumors

2022-12-20 | GSE216750 | GEO

The effects of Sindbis viral vectors on neuronal function

Project description:Viral vectors are attractive tools to express genes in neurons. Transduction of neurons with a recombinant, replication-deficient Sindbis viral vector is a method of choice for studying the effects of short-term protein overexpression on neuronal function. However, to which extent Sindbis by itself may affect neurons is not fully understood. We assessed effects of neuronal transduction with a Sindbis viral vector on the transcriptome and proteome in organotypic hippocampal slice cultures, and analyzed the electrophysiological properties of individual CA1 neurons, at 24h and 72h after viral vector injection. Whereas Sindbis caused substantial gene expression alterations, changes at the protein level were less pronounced. Alterations in transcriptome and proteome were predominantly limited to proteins involved in mediating anti-viral innate immune responses. Sindbis transduction did not affect the electrophysiological properties of individual neurons: the membrane potential, excitability and synaptic currents were similar between transduced and nontransduced CA1 neurons up to 72h after Sindbis injection. We conclude that Sindbis viral vectors are suitable for studying short-term effects of a protein of interest on electrophysiological properties of neurons, but not for studies on the regulation of gene expression.

2019-08-26 | PXD013634 | Pride

Sindbis survivors

Project description:Microarray analysis comparing cells that are resistant to Sindbis virus-induced cell death (clones 9, 43) versus cells that are sensitive to Sindbis virus-induced cell death (WT293) Keywords = Sindbis alphavirus functinal phenotype Keywords: repeat sample

2004-05-01 | GSE1264 | GEO

Sindbis virus

Project description:Sindbis virus Raw sequence reads

| PRJNA361123 | ENA

Expression profile of adult Drosophila melanogaster expressing a self-replicating RNA of Sindbis virus

Project description:Alphaviruses establish a persistent infection in arthropod vectors, which is essential for effective transmission of the virus to vertebrate hosts. The development of persistence in insects is not well understood, although it is thought to involve the innate immune response. Using a transgenic fly system (SINrep) expressing a self-replicating viral genome, we have previously demonstrated the antiviral response of the Drosophila Imd (Immune Deficiency) and Jak-STAT innate immunity pathways. In the current study, microarray analysis of SINrep flies in comparison to control GFP flies aims to detect genes that are sensitive to Sindbis viral RNA replication.

2013-01-31 | GSE42726 | GEO

Viral small RNAs in Sindbis virus-infected mammalian cells

Project description:Small RNAs play a critical role in host-pathogen interaction. In insects, for instance, small RNA-mediated silencing or RNA interference (RNAi) represents the main antiviral defense system. However, the antiviral role of RNAi has not been clearly proven in higher vertebrates. On the contrary, it is well established that the cell response relies on the recognition of viral RNAs by host pattern recognition receptors (PRR) to trigger the activation of the interferon pathway. Based on this evidence, we wished to contribute to this research field by identifying and characterizing small non-coding RNAs produced in mammalian cells upon RNA virus infection. We focused on Sindbis virus (SINV), the prototypical arbovirus, which by definition, is able to infect both vertebrate hosts and invertebrate vectors and triggers the interferon pathway or RNAi, respectively.

2013-11-19 | GSE48831 | GEO

Transcription profiling of resistant and sensitive human cell lines infected with Sindbis virus

2007-08-03 | E-GEOD-1264 | biostudies-arrayexpress

Sindbis virus

Project description:Sindbis virus structural polyprotein -1 PRF deep mutational scan

| PRJNA720960 | ENA

Expression profile of adult Drosophila melanogaster expressing a self-replicating RNA of Sindbis virus

2013-01-31 | E-GEOD-42726 | biostudies-arrayexpress

Nanostring transcriptomic analysis of lungs from antiChemR23 treated and untreated 4T1-bearing mice

Project description:Nanostring transcriptomic analysis of lungs from antiChemR23 treated and untreated 4T1-bearing mice

| PRJNA903164 | ENA