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Combination treatment of PTUPB with enzalutamide in C4-2B MDVR cells

ABSTRACT: Combination treatment of PTUPB with enzalutamide in C4-2B MDVR cells

PROVIDER: PRJNA895368 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22078065_1.fastq.gz	Fastqsanger.gz
	SRR22078065_2.fastq.gz	Fastqsanger.gz
	SRR22078066_1.fastq.gz	Fastqsanger.gz
	SRR22078066_2.fastq.gz	Fastqsanger.gz
	SRR22078067_1.fastq.gz	Fastqsanger.gz

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Expression data from prostate cancer cell lines C4-2B (enzalutamide sensitive) and C4-2B-MDVR (enzalutamide resistant) cells

Project description:Prostate cancer C4-2B cells were cultured in enzalutamide in a dose-escalation manner. After sixty passages cells were resistant to enzalutamide, with a specific sets of genes been deregulated. We performed global gene expression analysis by cDNA microarrays to identify genes responsible for enzalutamide resistance in C4-2B-MDVR cells. Enzalutamide resistant C4-2B-MDVR cells were selected from C4-2B cells during long time enzalutamide treatment. Genes responsible for enzalutamide resistance were identified using C4-2B vs. C4-2B-MDVR RNA extraction and hybridization on Affymetrix microarrays.

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Combination treatment of PTUPB with enzalutamide in C4-2B MDVR cells

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Transcriptome analysis of Enzalutamide-resistant C4-2B (C4-2B MDVR) cells treated with Indocin.

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Transcriptome analysis of Enzalutamide-resistant C4-2B (C4-2B MDVR) cells treated with Indocin.

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