Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [Hi-C]

ABSTRACT: Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [Hi-C]

PROVIDER: PRJNA897009 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity

Project description:Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity

| PRJNA897006 | ENA

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [CUT&TAG]

Project description:Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [CUT&TAG]

| PRJNA896521 | ENA

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [RNA-seq]

Project description:Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [RNA-seq]

| PRJNA896528 | ENA

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [ChIP-seq]

Project description:Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [ChIP-seq]

| PRJNA958250 | ENA

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [Hi-C]

Project description:Chromatin conformation reorganization is emerging as an important layer of regulation for gene expression and lineage specification. Yet, how lineage-specific transcription factors contribute to the establishment of cell type-specific 3D chromatin architecture in the immune cells remains unclear, especially for the late stages of T cell subset differentiation and maturation. Regulatory T cells (Treg) are mainly generated in the thymus as a subpopulation of T cells specializing in suppressing excessive immune responses. Here, by comprehensively mapping 3D chromatin organization during Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additionally, the binding sites of Foxp3, a Treg lineage specifying transcription factor, were highly enriched at Treg-specific chromatin loop anchors. Further comparison of the chromatin interactions between wide-type Tregs versus Treg cells from Foxp3 knock-in/knockout or newly-generated Foxp3 domain-swap mutant mouse revealed that Foxp3 was essential for the establishment of Treg-specific 3D chromatin architecture, although it was not dependent on the formation of the Foxp3 domain-swapped dimer. These results highlighted an underappreciated role of Foxp3 in modulating Treg-specific 3D chromatin structure formation.

2023-06-14 | GSE217144 | GEO

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [ChIP-seq]

2023-06-14 | GSE230330 | GEO

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [RNA-seq]

2023-06-14 | GSE216984 | GEO

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity [CUT&TAG]

2023-06-14 | GSE216982 | GEO

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-06-14 | GSE217147 | GEO

Capture of TAD reorganization endows variant patterns of gene transcription (Hi-C)

Project description:TAD (Topologically Associating Domain) reorganization occurs commonly in cell nucleus and contributes to gene activation and inhibition through separation or fusion of adjacent TADs. However, identification of functional genes impacted by TAD alteration and revealing of TAD-reorganization mechanism underlying gene transcription remain to be fully elucidated. Here, we firstly developed a novel approach termed Inter3D to specifically dig out genes regulated by TAD reorganization. By constructing the comprehensive TAD reorganization medicating epigenomic landscapes in tumor cells, we showed that TAD separation interrupted the intrachromosomal loop at MYL12B locus and abrogated its transcription, while TAD fusion generated the chromosomal interaction and triggered CYP27B1 activation. Our study provides a comprehensive insight into capture of TAD rearrangement-mediated gene loci and moves towards recognizing the functional role of TAD reorganization in gene transcription.

2024-04-29 | GSE230795 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data