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Gene profiling changes in mouse bone marrow derived macrophages upon SUMOylation inhibition

ABSTRACT: Gene profiling changes in mouse bone marrow derived macrophages upon SUMOylation inhibition

PROVIDER: PRJNA899817 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22245248.fastq.gz	Fastqsanger.gz
	SRR22245249.fastq.gz	Fastqsanger.gz
	SRR22245250.fastq.gz	Fastqsanger.gz
	SRR22245251.fastq.gz	Fastqsanger.gz

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Gene profiling changes in mouse bone marrow derived macrophages upon SUMOylation inhibition

Project description:SUMOylation, a posttranslational modification, regulates protein function by covalent attachment of small ubiquitin-like modifier (SUMO) proteins to a lysine (Lys) residue on target proteins. Here we use ML-792, a selective SUMO-activating enzyme (SAE) inhibitor, to inhibit global SUMOylation in macrophages derived from bone marrow of C57BL/6 mice. Mouse bone marrow cells isolated from 6–10 weeks C57BL/6 mice were cultured in IMDM medium supplemented with 10% (vol/vol) FBS and 10 ng/mL of macrophage colony-stimulating factor (M-CSF). After 6–8 days of differentiation, the cells were treated with vehicle or ML-792 at 0.5 μM for 24 h. Total RNA was purified using miRNeasy RNA isolation kit (Qiagen) then Ribo-Zero RNA-seq was performed.

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Project description:Purpose: To determine H3K4me3 chromatin profile in UBC9WT and UBC9KO BMDC before and after LPS stimulation. Methods: H3K4me3 chromatin profile was determined by sequencing UBC9 WT and UBC9 KO BMDC chromatin immunoprecipitated with antibody specific for H3K4me3. Results: We show differential chromatin profile for H3K4me3 on the ifnb1 locus between UBC9 KO cells and UBC9 WT. Conclusions: Loss of SUMOylation causes a deregulation of ifnb1 transcription activation mark. A study of H3K4me3 chromatin profile in UBC9 WT and UBC9 KO Bone Marrow derived Dendritic Cells.

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