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Identification of LGR6-associated genes in NSCLC

ABSTRACT: Identification of LGR6-associated genes in NSCLC

PROVIDER: PRJNA902646 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22318659_1.fastq.gz	Fastqsanger.gz
	SRR22318659_2.fastq.gz	Fastqsanger.gz
	SRR22318660_1.fastq.gz	Fastqsanger.gz
	SRR22318660_2.fastq.gz	Fastqsanger.gz
	SRR22318661_1.fastq.gz	Fastqsanger.gz

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Identification of LGR6-associated genes in NSCLC

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LGR6 marks nephron progenitor cells

Project description:Background: Nephron progenitor cells (NPCs) undergo a stepwise process to generate all mature nephron structures. Mesenchymal to epithelial transition (MET) is considered a multi-step process of NPC differentiation to ensure progressive establishment of new nephrons. However, despite this important role, to date, no marker for NPCs undergoing MET in the nephron exists. Results: Here, we identify LGR6 as a NPC marker, expressed in very early cap mesenchyme, pre-tubular aggregates, renal vesicles and in segments of S-shaped bodies, following the trajectory of MET. By using a lineage tracing approach in embryonic explants in combination with confocal imaging and single-cell RNA sequencing, we provide evidence for the multiple fates of LGR6+ cells during embryonic nephrogenesis. Moreover, by using long-term in vivo lineage tracing, we show that postnatal LGR6+ cells are capable of generating the multiple lineages of the nephrons. Conclusion: Given the profound early mesenchymal expression and MET signature of LGR6+ cells, together with the lineage tracing of mesenchymal LGR6+ cells, we conclude that LGR6+ cells contribute to all nephrogenic segments by undergoing MET. LGR6+ cells can therefore be considered an early committed NPC population during embryonic and postnatal nephrogenesis with potential regenerative capability.

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RNA-Seq of Lgr6 positive and negative cells in mouse mammary gland

Project description:Lgr6-positive cells have been shown to label stem/progenitors cells in several tissues including tongue and skin. However their role in mammary gland has never been investigated. Here we used Lgr6-eGFP-IRES-CreER2 mice to isolate and characterize Lgr6-positive population in mammary gland of 5-week old female mice. Examination of transcriptional differences between Lgr6 positive and negative cells

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