Project description:In Burkitt lymphoma (BL), a network consisting of MYC, MYC-repressed miR-150 and miR-150 targets MYB and ZDHHC11 has been established. This network plays an important role on the growth of BL cells. Here, we performed gene expression analysis to identify targets of ZDHHC11.
Project description:B-cell leukemia/lymphoma 11B (Bcl11b) is a transcription factor showing predominant expression in the striatum. To date, there are no known gene targets of Bcl11b in the nervous system. Here, we define targets for Bcl11b in striatal cells by performing genome-wide expression profiling. Transcriptome-wide analysis revealed that 694 genes were significantly altered in striatal cells over-expressing Bcl11b, including genes showing striatal-enriched expression similar to Bcl11b. Functional analysis on the gene target list identified significant association of Bcl11b to brain-derived neurotrophic factor/neurotrophin signaling. These data implicate Bcl11b as a novel regulator of the BDNF signaling pathway, which is disrupted in many neurological disorders.
Project description:Using ChIP-seq technology, we tried to find out the whole genome targets for IRF2 in mouse colorectal cancer (CRC) cells. More than 7000 genes were defined as the target of IRF2.
Project description:Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations find a uniqueness in oligodendroglioma