Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Immune Editing Roles of SIGLEC15 in Tumor Microenvironment of Hepatocellular Carcinoma

ABSTRACT: Immune Editing Roles of SIGLEC15 in Tumor Microenvironment of Hepatocellular Carcinoma

PROVIDER: PRJNA903797 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22355253.fastq.gz	Fastqsanger.gz
	SRR22355254.fastq.gz	Fastqsanger.gz
	SRR22355255.fastq.gz	Fastqsanger.gz
	SRR22355256.fastq.gz	Fastqsanger.gz
	SRR22355476_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Immune Editing Roles of SIGLEC15 in Tumor Microenvironment [scRNA-seq]

Project description:Immune Editing Roles of SIGLEC15 in Tumor Microenvironment [scRNA-seq]

| PRJNA903802 | ENA

Tumor immune microenvironment difference primary and metastatic hepatocellular carcinoma

Project description:Tumor immune microenvironment difference primary and metastatic hepatocellular carcinoma

| PRJNA591784 | ENA

MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma

Project description:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in the world. Mitochondrial fission regulator 2 (MTFR2) is involved in the development of various cancers. However, the roles of MTFR2 in HCC remain unknown. In this study, we conducted a comprehensive analysis of MTFR2 in HCC, which was generated from integrative MTFR2 analyses of eight HCC cell lines, and three datasets (public dataset, real-world dataset, immunotherapy dataset) derived from bulk HCC tissues, survival and immunotherapy data. We demonstrated that the expression level of MTFR2 is up-regulated in HCC, leading to poor prognosis. MTFR2 is positively correlated with the level of immune cell infiltration, multiple immune checkpoints and immunotherapy response prediction pathways, and act important role in cancer-immunity cycle. In conclusion, our work indicates that MTFR2 can shape a barrier of immune microenvironment and result in poor prognosis in hepatocellular carcinoma, but the immune barrier may be broken by immunotherapy.

2022-09-01 | GSE212529 | GEO

MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma

Project description:MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma

| PRJNA875910 | ENA

Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression

Project description:Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression

| PRJNA1119415 | ENA

Molecular Characteristics and Biological Functions of Hypoxic Microenvironment in Hepatocellular Carcinoma

Project description:Molecular Characteristics and Biological Functions of Hypoxic Microenvironment in Hepatocellular Carcinoma

| PRJNA833336 | ENA

Role of SIRT1 in human hepatocellular carcinoma

Project description:To investigate the specific roles of SIRT1 in the development of hepatocellular carcinoma, we employed large-scale gene expression analysis to identify the molecular signature that may affect enabling characteristics of cancer cells. Differentially expressed genes were analyzed on the SNU-182 cells transfected with SIRT1 siRNA and recapitulated molecular signatures that related to hallmarks of cancer. SIRT1 expression in hepatocellular carcinoma was analyzed by RT-PCR and western blot. RNA interference-mediated protein knockdown method was used to investigate oncogenic potential of SIRT1 in hepatocelluar carcinoma

2012-03-01 | E-GEOD-32066 | biostudies-arrayexpress

The Tumor Microenvironment Shapes Innate Lymphoid Cells in Patients with Hepatocellular Carcinoma

Project description:The Tumor Microenvironment Shapes Innate Lymphoid Cells in Patients with Hepatocellular Carcinoma

| PRJNA744903 | ENA

The Tumor Microenvironment Shapes Innate Lymphoid Cells in Patients with Hepatocellular Carcinoma

Project description:The Tumor Microenvironment Shapes Innate Lymphoid Cells in Patients with Hepatocellular Carcinoma

| PRJNA745080 | ENA

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma [WES]

Project description:Hepatocellular carcinoma (HCC) is a highly heterogenous disease associated with an equally dynamic tumor microenvironment (TME). We generated somatic HCC mouse models bearing clinically-relevant oncogenic driver combinations that faithfully recapitulated different human HCC subclasses. Using WES data, we explored the tumor mutation frequencies between models and compared them with human datasets.

2024-04-27 | GSE216716 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data