Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Uncovering the epigenomic determinants of kidney vascular development [scATAC-seq]

ABSTRACT: Uncovering the epigenomic determinants of kidney vascular development [scATAC-seq]

PROVIDER: PRJNA904336 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22382560_1.fastq.gz	Fastqsanger.gz
	SRR22382560_2.fastq.gz	Fastqsanger.gz
	SRR22382561_1.fastq.gz	Fastqsanger.gz
	SRR22382561_2.fastq.gz	Fastqsanger.gz
	SRR22382562_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Uncovering the epigenomic determinants of kidney vascular development

Project description:Uncovering the epigenomic determinants of kidney vascular development

| PRJNA904328 | ENA

Uncovering the epigenomic determinants of kidney vascular development [scRNA-seq]

Project description:Uncovering the epigenomic determinants of kidney vascular development [scRNA-seq]

| PRJNA904335 | ENA

Uncovering the epigenomic determinants of kidney vascular development [scATAC-seq]

Project description:Renin cells are essential for survival. They control the morphogenesis of the kidney arterioles, and the composition and volume of our extracellular fluid, arterial blood pressure, tissue perfusion, and oxygen delivery. Renin cells and associated arteriolar cells descend from FoxD1+ progenitor cells. The chromatin states and transcription factors that determine the differentiation of these cells into those that compose the kidney vasculature are unknown. To answer these questions, we isolated progenitors and their descendants at different embryonic and postnatal stages, and using integrated scRNA-seq and scATAC-seq established the developmental trajectory that leads to the mosaic of cells that compose the kidney arterioles. We constructed a single-cell atlas of chromatin accessibility and gene expression profiles-including the critical transcription factors that determine the identity and fate of the mosaic of cells that occur during kidney vascular development. Furthermore, we identified the factors that determine the elusive, myo-endocrine adult renin-secreting juxtaglomerular cell.

2023-07-06 | GSE218568 | GEO

Uncovering the epigenomic determinants of kidney vascular development [scRNA-seq]

2023-07-06 | GSE218569 | GEO

Uncovering the epigenomic determinants of kidney vascular development

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-06 | GSE218570 | GEO

scATAC-seq of mouse Plasmodium-specific CD4+ T cells

Project description:Plasmodium-specific CD4+ T cells from mice infected with Plasmodium chabaudi chabaudi AS parasites were recovered at Days 0, 4, 7, and 32 to undergo processing and to generate scATAC-seq dataset. At Day 7, CXCR5+ and CXCR6+ cells were recovered separately. At Day 32, mice were administered with either saline or artesunate (intermittent artesunate therapy - IAT). scATAC-seq dataset was analysed to investigate epigenomic landscapes of CD4+ T cells from effector to memory states.

2020-10-14 | E-MTAB-9402 | biostudies-arrayexpress

The epigenomic landscape of cognitive stimulation in the context of aging in mouse dorsal hippocampus - SWATH

Project description:Aging is a universal biological phenomenon linked to many diseases, such as cancer or neurodegeneration. However, the molecular mechanisms underlying aging, or how lifestyle interventions such as cognitive stimulation can ameliorate this process, are yet to be clarified. Here, we performed a multi-omic profiling, including RNA-seq, ATAC-seq, ChIP-seq, EM-seq, SWATH-MS and single cell Multiome scRNA and scATAC-seq, in the dorsal hippocampus of young and old mouse subjects which were subject to cognitive stimulation using the paradigm of environmental enrichment. In this study we were able to describe the epigenomic landscape of aging and cognitive stimulation.

2023-09-29 | PXD045567 | Pride

Molecular determinants of nephron vascular specialization in the kidney

Project description:Molecular determinants of nephron vascular specialization in the kidney

| PRJNA573072 | ENA

Molecular determinants of nephron vascular specialization in the kidney

Project description:The kidney vasculature is specialized to filter waste products from the blood, regulate blood pressure, and balance electrolytes. Although recent advances in stem cell studies have enabled the partial generation of kidney tissues in vitro, recapitulating the complex vascular structures of the kidney remains a daunting task. The molecular pathways that specify and sustain kidney vascular heterogeneity to perform these diverse tasks are not well characterized. Here, we have employed high throughput bulk and single-cell RNA sequencing of the non-lymphatic vasculature of the kidney to uncover the progression of pathways that dictate the developmental transition of nephrogenesis and vascular zonation from embryos to adulthood. We show that glomeruli and its associated vessels, manifest vascular-specific signatures expressing defined transcription factors, ion channels, solute transporters, and paracrine factors choreographing kidney functions. Notably, the ontology of the glomerulus coincides with induction of several unique transcription factors, including Tbx3, Gata5, Prdm1, and Pbx1. Selective deletion of Tbx3 in endothelial cells result in glomerular hypoplasia, microaneurysms and regressed fenestrations leading to fibrosis. Unraveling the molecular determinants of kidney vascular signatures will lay the foundation for rebuilding nephrons and understanding the pathogenesis of kidney diseases.

2019-09-20 | GSE137786 | GEO

Temporal and functional determinants of intra-hepatic vascular homeostatic specialization

Project description:Temporal and functional determinants of intra-hepatic vascular homeostatic specialization

| PRJNA723027 | ENA