Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [Hi-C]

ABSTRACT: Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [Hi-C]

PROVIDER: PRJNA904797 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22398603_1.fastq.gz	Fastqsanger.gz
	SRR22398603_2.fastq.gz	Fastqsanger.gz
	SRR22398604_1.fastq.gz	Fastqsanger.gz
	SRR22398604_2.fastq.gz	Fastqsanger.gz
	SRR22398605_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 25

Similar Datasets

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome

Project description:Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome

| PRJNA904794 | ENA

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [WGS]

Project description:Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [WGS]

| PRJNA904798 | ENA

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [Nanopore]

Project description:Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [Nanopore]

| PRJNA904800 | ENA

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [RNA-seq]

Project description:Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [RNA-seq]

| PRJNA904796 | ENA

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [CUT&RUN]

Project description:Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [CUT&RUN]

| PRJNA904799 | ENA

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [ChIP-seq]

Project description:Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [ChIP-seq]

| PRJNA904795 | ENA

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [Nanopore]

Project description:Short tandem repeat (STR) instability causes transcriptional silencing in several repeat expansion disorders. In fragile X syndrome (FXS), mutation-length expansion of a CGG STR represses FMR1 via local DNA methylation. Here, we find Megabase-scale H3K9me3 domains on autosomes and encompassing FMR1 on the X-chromosome in induced pluripotent stem cell (iPSC)-derived neural progenitors, B-cells, and fibroblasts with mutation-length CGG expansion. H3K9me3 domains connect via inter-chromosomal interactions and demarcate severe misfolding of TADs and loops. They harbor long synaptic genes replicating at the end of S phase, replication stress-induced double strand breaks, and STRs prone to stepwise somatic instability. CRISPR engineering of the full-mutation CGG to premutation-length reverses H3K9me3 domains on the X-chromosome and multiple autosomes, refolds TADs, and restores expression. H3K9me3 domains also arise in a subset of normal-length iPSCs with increased STR instability burden. Our results reveal Mb-scale heterochromatinization and trans interactions among chromosomes susceptible to repeat genetic instability.

2023-12-21 | GSE218679 | GEO

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [WGS]

2023-12-21 | GSE218678 | GEO

Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome [CUT&RUN]

2023-12-21 | GSE218677 | GEO