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The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes [RNA-seq]

ABSTRACT: The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes [RNA-seq]

PROVIDER: PRJNA904814 | ENA |

REPOSITORIES: ENA

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The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genesed genes [WGBS]

Project description:The brushtail possum, Trichosurus vulpecula, is threatened in parts of its native range in Australia, but has also become a devastating mammalian pest following introduction into New Zealand from the mid 1800s. We have completed the first chromosome-level assembly of the possum genome and, using nuclear and mitochondrial analyses, traced southern New Zealand possums to distinct Tasmanian and mainland Australian subspecies, which have subsequently hybridised. This admixture is reflected in high levels of genetic diversity within New Zealand populations despite a founding bottleneck. Functional genomics revealed unique adaptations to altricial birth and extending weaning, including novel chemo-sensory genes, and at least four genes with imprinted, parent-specific expression not yet detected in other species (MLH1, EPM2AIP1, UBP1 and GPX7). We found that reprogramming of possum germline imprints and the wider epigenome was similar to eutherian mammals, except onset occurs after birth. Together, our data and analysis is useful for genetic-based control and conservation of possums, and contributes to understanding of the evolution of novel mammalian epigenetic traits such as germline methylation erasure and genomic imprinting.

2022-11-29 | GSE218734 | GEO

The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes [RNA-seq]

2022-11-29 | GSE218695 | GEO

The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes

Project description:The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes

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The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genesed genes [WGBS]

Project description:The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genesed genes [WGBS]

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The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-11-29 | GSE218811 | GEO

The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes.

Project description:Combining genome assembly with population and functional genomics can provide valuable insights to development and evolution, as well as tools for species management. Here, we present a chromosome-level genome assembly of the common brushtail possum (Trichosurus vulpecula), a model marsupial threatened in parts of their native range in Australia, but also a major introduced pest in New Zealand. Functional genomics reveals post-natal activation of chemosensory and metabolic genes, reflecting unique adaptations to altricial birth and delayed weaning, a hallmark of marsupial development. Nuclear and mitochondrial analyses trace New Zealand possums to distinct Australian subspecies, which have subsequently hybridised. This admixture allowed phasing of parental alleles genome-wide, ultimately revealing at least four genes with imprinted, parent-specific expression not yet detected in other species (MLH1, EPM2AIP1, UBP1 and GPX7). We find that reprogramming of possum germline imprints, and the wider epigenome, is similar to eutherian mammals except onset occurs after birth. Together, this work is useful for genetic-based control and conservation of possums, and contributes to understanding of the evolution of novel mammalian epigenetic traits.

| S-EPMC10582058 | biostudies-literature

Coat colour of brushtail possum

Project description:The fur of the common brushtail possum (Trichosurus vulpecula), a model marsupial, is lightweight, soft and has superior insulation properties. Two predominate fur colours exisit: grey or black. RNA-sequencing of skin from grey (n=3) and black (n=3) possums was performed to investigate gene expression changes between these colour morphs.

2024-03-10 | GSE250237 | GEO

Project description:The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes

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Coat colour of brushtail possum

Project description:Coat colour of brushtail possum

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Project description:Transcriptome of the New Zealand brushtail possum (Trichosurus vulpecula)

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