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MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33

ABSTRACT: MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33

PROVIDER: PRJNA905825 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22422812_1.fastq.gz	Fastqsanger.gz
	SRR22422812_2.fastq.gz	Fastqsanger.gz
	SRR22422813_1.fastq.gz	Fastqsanger.gz
	SRR22422813_2.fastq.gz	Fastqsanger.gz
	SRR22422814_1.fastq.gz	Fastqsanger.gz

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MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-09-10 | GSE218834 | GEO

MrgprA3 neurons selectively control myeloid-derived IL-33 for IL-17 dependent cutaneous immunity [ATAC-Seq]

Project description:MrgprA3 neurons selectively control myeloid-derived IL-33 for IL-17 dependent cutaneous immunity [ATAC-Seq]

| PRJNA905826 | ENA

MrgprA3 neurons selectively control myeloid-derived IL-33 for IL-17 dependent cutaneous immunity [scRNA-Seq]

Project description:MrgprA3 neurons selectively control myeloid-derived IL-33 for IL-17 dependent cutaneous immunity [scRNA-Seq]

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MrgprA3 neurons selectively control myeloid-derived IL-33 for IL-17 dependent cutaneous immunity [bulk RNA-Seq]

Project description:MrgprA3 neurons selectively control myeloid-derived IL-33 for IL-17 dependent cutaneous immunity [bulk RNA-Seq]

| PRJNA905814 | ENA

Molecular signature of pruriceptive MrgprA3+ neurons

Project description:We performed RNA sequencing of genetically labeled MrgprA3+ neurons under both naïve and allergic contact dermatitis conditions. Our results revealed the unique molecular signature of itch-sensing neurons and the distinct transcriptional profile changes that result in response to dermatitis. We found enrichment of nine Mrgpr family members and two histamine receptors in MrgprA3+ neurons, suggesting that MrgprA3+ neurons are a direct neuronal target for histamine and Mrgprs agonists. In addition, Ptpn6 and Pcdh12 were identified as novel and highly selective markers of MrgprA3+ neurons. We also discovered that MrgprA3+ neurons respond to skin dermatitis in a way that is unique from other sensory neurons by regulating a combination of transcriptional factors, ion channels, and key molecules involved in synaptic transmission. These results significantly increase our knowledge of itch transmission and uncover potentially novel targets for combating itch.

2020-03-13 | GSE146876 | GEO

MrgprA3 neurons selectively control myeloid-derived IL-33 for IL-17 dependent cutaneous immunity [ATAC-Seq]

Project description:Skin contains poorly understood interdependent cellular networks that facilitate barrier integrity and host immunity, including neurons, and myeloid cells; the latter of which intrinsically express the pleiotropic cytokine IL-33. This work shows selective suppression of IL-33 expression in myeloid cells by activation of itch-sensing neurons bearing the Mas-related G protein receptor A3 (A3). Optogenetic activation of A3 neurons also increased IL-17-expressing γδ T cells, epidermal thickening, and resistance to the human pathogen Schistosoma mansoni, partially through the neuropeptide CGRP. Cell-intrinsic loss of IL-33 in myeloid cells alters chromatin conformation, basally elevates expression and release of IL-17-inducing cytokines (e.g., IL-1β, IL-6), and expands macrophage and cDC2 differentiation, driving both tissue pathology (e.g., epidermal thickening, keratinocyte hyperplasia) and resistance to helminth infection. Our findings suggest a mechanism of cellular cross-talk allowing “itch” neuron activation to alter myeloid composition and cytokine expression patterns for reshaping skin architecture and driving immunity

2024-09-12 | GSE218833 | GEO

MrgprA3 neurons selectively control myeloid-derived IL-33 for IL-17 dependent cutaneous immunity [scRNA-Seq]

2024-09-12 | GSE218825 | GEO

MrgprA3 neurons selectively control myeloid-derived IL-33 for IL-17 dependent cutaneous immunity [bulk RNA-Seq]

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Molecular signature of pruriceptive MrgprA3+ neurons

Project description:Molecular signature of pruriceptive MrgprA3+ neurons

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unicellular eukaryotes and helminths

Project description:Unicellular eukaryotes and helminths Targeted loci environmental

| PRJNA495046 | ENA