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Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2 [ChIP-Seq]

ABSTRACT: Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2 [ChIP-Seq]

PROVIDER: PRJNA906505 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22443714_1.fastq.gz	Fastqsanger.gz
	SRR22443714_2.fastq.gz	Fastqsanger.gz
	SRR22443715.fastq.gz	Fastqsanger.gz
	SRR22443715_1.fastq.gz	Fastqsanger.gz
	SRR22443715_2.fastq.gz	Fastqsanger.gz

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Similar Datasets

Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2 [RNA-Seq]

Project description:The mechanism by which endometriosis, a common gynecological disease characterized by chronic pelvic pain and infertility, causes infertility remains elusive. Luteinized unruptured follicle syndrome, the most common type of ovulatory dysfunction, is a cause of endometriosis-associated infertility involving reduced numbers of retrieved and mature oocytes. Ovulation is controlled by luteinizing hormone and paracrine signals produced within the follicle microenvironment. Generally, interleukin (IL)-1β is elevated in endometriosis follicular fluid, whereby it amplifies ovulation signals by activating extracellular-regulated kinase 1/2 and CCAAT/enhancer binding protein β pathways. However, this amplification of ovulation by IL-1β does not occur in patients with endometriosis. To illuminate the mechanism of ovulatory dysfunction in endometriosis, we analyzed the impact of oxidative stress and IL-1β expression in endometriosis follicles. We found that oxidative stress decreased EZH2 expression and reduced H3K27Me3 levels in endometriosis ovarian granulosa cells (GCs). Selective Ezh2 depletion in mice ovarian GCs reduced fertility by disturbing cumulus-oocyte complex expansion and reducing epidermal growth factor-like factor expression. Gene expression and H3K27Me3 ChIP-sequencing of GCs revealed IL-1 receptor 2 (IL-1R2), a high-affinity IL-1β-receptor that suppresses IL-1β-mediated inflammatory cascades during ovulation, as a crucial target gene of the EZH2-H3K27Me3 axis. Moreover, IL-1β addition did not restore ovulation upon Ezh2 knockdown, indicating a vital function of IL-1R2 in endometriosis. Thus, our findings show that reducing EZH2 and H3K27Me3 in GCs suppressed ovulatory signals by increasing IL-1R2 expression, which may ultimately contribute to endometriosis-associated infertility.

2025-02-28 | GSE218980 | GEO

Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2 [ChIP-Seq]

2025-02-28 | GSE218976 | GEO

Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2

Project description:Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2

| PRJNA906509 | ENA

Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2 [RNA-Seq]

Project description:Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2 [RNA-Seq]

| PRJNA906513 | ENA

Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-02-28 | GSE218984 | GEO

Pathophysiological role of MIG-6 and ERBB2 in progesterone resistance and endometriosis-related infertility.

Project description:MIG-6 loss caused progesterone resistance through ERBB2 overexpression in non-receptive endometrium of endometriosis-related infertility. We used microarrays to understand the molecular mechanisms of progesterone resistance in infertility

2019-11-30 | GSE138185 | GEO

Expression profiles of EMs-related infertility and tubal factor infertility granulosa cells revealed by RNA-seq

Project description:Granulosa cells are essential to the growth, development, and maturation of oocytes and follicles. In patients with EMs-related infertility, follicle maturation disorders, poor oocyte quality may be closely related to GCs in the follicle. However, the molecular biological mechanism of GCs in EMs-related infertility has not been reported. Therefore, we tried to explore the possible causes of EMs-related infertility through the study of ovarian GCs in patients with EMs-related infertility and tubal factor infertility.

2021-03-05 | GSE168214 | GEO

Analysis of lncRNA expression in endometriosis infertility, tubal disease infertility and normal subjects

Project description:Analysis of lncRNA expression in endometriosis infertility, tubal disease infertility and normal subjects

| PRJNA1090075 | ENA

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity

Project description:Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity

| PRJNA846064 | ENA

mRNA, lncRNA and circular RNA expression profiles and ceRNA network construction of granulosa cells in ovarian endometriosis

Project description:RNA sequencing was conducted for RNA expression profiling from GCs of five women with ovarian endometriosis and five with tubal factor infertility. The differential expression of mRNAs, lncRNAs, and circRNAs was compared. Then, the lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA networks were constructed by co-expressing lncRNA/circRNA and mRNAs.

2024-12-25 | GSE192636 | GEO

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