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Effect of aging on gene expression in round spermatids from Brown Norway rats

ABSTRACT: Effect of aging on gene expression in round spermatids from Brown Norway rats

PROVIDER: PRJNA906629 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22450575_1.fastq.gz	Fastqsanger.gz
	SRR22450575_2.fastq.gz	Fastqsanger.gz
	SRR22450576_1.fastq.gz	Fastqsanger.gz
	SRR22450576_2.fastq.gz	Fastqsanger.gz
	SRR22450577_1.fastq.gz	Fastqsanger.gz

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Effect of aging on gene expression in round spermatids from Brown Norway rats

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Expression data from purified control and BrdtΔBD1 round spermatids.

Project description:Brdt is a testis specific member of a family of chromatin interacting proteins. All of the family members have been shown to regulate transcription. Brdt is highly expressed in round spermatids, and may play a role in transcriptional regulation in these cells. We investigated transcriptional changes in mutant round spermatids that were homozygous for a mutation in which the first bromodomain of Brdt was removed. Round spermatids were purified from seven adult animals of each genotype for each Affymetrix microarray. Purity of round spermatids was assessed by propidium iodide staining.

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Histone methylation regulates gene expression in the round spermatids to set the RNA payloads of sperm

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