The HAPSTR2 retrogene buffers stress signaling and resilience in mammals
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA907726 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR22499536_1.fastq.gz | Fastqsanger.gz | |||
| SRR22499536_2.fastq.gz | Fastqsanger.gz | |||
| SRR22499537_1.fastq.gz | Fastqsanger.gz | |||
| SRR22499537_2.fastq.gz | Fastqsanger.gz | |||
| SRR22499538_1.fastq.gz | Fastqsanger.gz |
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Project description:We recently identified HAPSTR1 (C16orf72) as a key component in a novel pathway which regulates the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding. Here, we identify a functional paralog to HAPSTR1: HAPSTR2. HAPSTR2 formed early in mammalian evolution, via genomic integration of a reverse transcribed HAPSTR1 transcript, and has since been preserved under purifying selection. HAPSTR2, expressed primarily in neural and germline tissues and a subset of cancers, retains established biochemical features of HAPSTR1 to achieve two functions. In normal physiology, HAPSTR2 directly interacts with HAPSTR1, markedly augmenting HAPSTR1 protein stability in a manner independent from HAPSTR1's canonical E3 ligase, HUWE1. Alternatively, in the context of HAPSTR1 loss, HAPSTR2 expression is sufficient to buffer stress signaling and resilience. Thus, we discover a mammalian retrogene which safeguards fitness.
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