Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mycobacterium ulcerans Agy99

ABSTRACT: Mycobacterium ulcerans Agy99 Transcriptome or Gene expression

PROVIDER: PRJNA907849 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22526847_1.fastq.gz	Fastqsanger.gz
	SRR22526847_2.fastq.gz	Fastqsanger.gz
	SRR22526848_1.fastq.gz	Fastqsanger.gz
	SRR22526848_2.fastq.gz	Fastqsanger.gz
	SRR22526849_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Mycobacterium ulcerans

Project description:Mycobacterium ulcerans Genome sequencing

| PRJNA1008572 | ENA

Mycobacterium ulcerans

Project description:Mycobacterium ulcerans Raw sequence reads

| PRJNA296792 | ENA

RNA-seq strategy to study Mycobacterium ulcerans adaptation within our original mouse model of spontaneous healing.

Project description:Mycobacterium ulcerans is the causal agent of Buruli ulcer, a chronic infectious disease and the third most common mycobacterial disease worldwide. Without early treatment, M. ulcerans provokes massive skin ulcers, caused by the mycolactone toxin, its main virulence factor. However, spontaneous healing may occur in Buruli ulcer patients several months or years after the disease onset. We have shown, in an original mouse model, that bacterial load remains high and viable in spontaneously healed tissues, suggesting that M. ulcerans switches to low levels of mycolactone production, adapting its strategy to survive in such a hostile environment. We investigated the regulation of mycolactone production, by using an RNA-seq strategy to study bacterial adaptation within our original mouse model of spontaneous healing. Pathway analysis and characterization of the tissue environment showed that the bacillus adapted to its new environment by modifying its metabolic activity and switching nutrient sources. Thus, M. ulcerans ensures its survival in healing tissues by reducing its secondary metabolism, leading to an inhibition of mycolactone synthesis and changes in cell wall composition. These findings shed new light on mycolactone regulation and pave the way for new therapeutic strategies.

2021-05-17 | GSE157956 | GEO

Mycobacterium ulcerans

Project description:Mycobacterium ulcerans Raw sequence reads (African sample panel)

| PRJNA313185 | ENA

Mycobacterium ulcerans

Project description:Whole genome sequencing of Mycobacterium ulcerans, an opportunistic pathogen

| PRJDB2463 | ENA

Mycobacterium ulcerans strain:JKD8049

Project description:Mycobacterium ulcerans strain:JKD8049 complete genome

| PRJNA771185 | ENA

Mycobacterium ulcerans strain:BS123

Project description:Mycobacterium ulcerans strain:BS123 Genome sequencing