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Site-specific development and progressive maturation of human tissue resident memory T cells over infancy and childhood

ABSTRACT: Site-specific development and progressive maturation of human tissue resident memory T cells over infancy and childhood

PROVIDER: PRJNA908789 | ENA |

REPOSITORIES: ENA

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Site-specific development and progressive maturation of human tissue resident memory T cells over infancy and childhood

Project description:Infancy and childhood are critical life stages for the generation of immune memory for protection against pathogens. This process has been challenging to elucidate in humans as most memory T cells reside in tissues. Here, we define localization, and developmental pathways of memory T cells in mucosal sites, lymphoid tissues, and blood from pediatric donors aged 0-10 years. We reveal that memory T cells preferentially localize in mucosal sites during infancy and accumulate more rapidly over childhood compared to blood and lymphoid organs. Mucosal memory T cells in infancy exhibit stem-like transcriptional profiles, but progressively adopt signatures of mature tissue resident memory T cells over childhood. Our results show that exposures during the formative years establish the landscape of immunity through tissue-specific generation and adaptation of memory T cells

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