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Fenofibrate lowers cardiac lipid accumulation and attenuates diabetic cardiomyopathy in db/db mice.

ABSTRACT: Fenofibrate lowers cardiac lipid accumulation and attenuates diabetic cardiomyopathy in db/db mice.

PROVIDER: PRJNA908835 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22534776_1.fastq.gz	Fastqsanger.gz
	SRR22534776_2.fastq.gz	Fastqsanger.gz
	SRR22534777_1.fastq.gz	Fastqsanger.gz
	SRR22534777_2.fastq.gz	Fastqsanger.gz
	SRR22534778_1.fastq.gz	Fastqsanger.gz

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Fenofibrate lowers cardiac lipid accumulation and attenuates diabetic cardiomyopathy in db/db mice.

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Project description:Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha, but there are reports that fenofibrate affects endothelial cells in PPARa-independent manner. In order to identify PPARa-dependently and PPARa-independently regulated transcripts we generated microarray data from human endothelial cells treated with fenofibrate with and without siRNA-mediated knock-down of PPARa.

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