Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of osteocytes mitochondria on chondrocytes

ABSTRACT: Effect of osteocytes mitochondria on chondrocytes

PROVIDER: PRJNA909166 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Effect of osteocytes mitochondria on OA chondrocytes

Project description:Effect of osteocytes mitochondria on OA chondrocytes

| PRJNA907788 | ENA

Effect of osteocytes mitochondria on chondrocytes

Project description:To investigate the regulatory role of MLO-Y4 mitochondria on chondrocytes, we isolated mitochondria from MLO-Y4 and transplanted to chondrocytes. We then performed gene expression profiling analysis using data obtained from RNA-seq of chondrocytes from vehicle group and mitochondria transplanted group.

2024-12-31 | GSE220168 | GEO

Effect of osteocytes mitochondria on OA chondrocytes

Project description:To investigate the regulatory role of MLO-Y4 mitochondria on OA chondrocytes, we isolated mitochondria from MLO-Y4 and transplanted to chondrocytes treated with IL-1β. We then performed gene expression profiling analysis using data obtained from RNA-seq of chondrocytes from vehicle group and mitochondria transplanted group.

2024-12-01 | GSE219238 | GEO

Osteocytes regulate transcortical blood vessel network by transferring mitochondria to endothelial cells in cortical bone

Project description:In this study, mitochondria were proved to be capable of delivering mitochondria to endothelial cells of transcortical blood vessel and promotes its angiogenesis. By utilizing RNA seq, we investigated the effect of osteocytes-derived mitochondria on endothelial cells.

2025-02-08 | GSE224786 | GEO

Effect of Notch2 in chondrocytes

Project description:Effect of Notch2 in chondrocytes

| PRJNA930413 | ENA

ActivinA effect on mouse articular chondrocytes

Project description:ActivinA effect on mouse articular chondrocytes

| PRJNA609946 | ENA

Nox4 effect on mouse articular chondrocytes

Project description:Nox4 effect on mouse articular chondrocytes

| PRJNA609945 | ENA

Rip3 effect on mouse articular chondrocytes

Project description:Rip3 effect on mouse articular chondrocytes

| PRJNA646977 | ENA

The effects of mitochondrial damages under stress or during aging on osteocytes networks homeostasis

Project description:Using oligomycin A-treated MLO-Y4 cells and primary murine aging osteocytes as a model of cells with mitochondrial dysfunction, it is demonstrated that when mitochondria are damaged, osteocytes tend to release signaling compounds including adenosine diphosphate. We identified that the nucleotide membrane receptors P2Y2 and P2Y6 transduced the ADP signal to Mfn2, a critical regulator of osteocyte mitochondrial transfer. Whole RNA sequencing (RNA-seq) analysis of mouse cortical bone showed that mitochondrial metabolism is impaired in aged osteocytes, and there are more extracellular nucleotides released into the matrix in cortical bone in aged mice as compared to that in young mice. Aging decreases expression levels of P2Y2/P2Y6 and Mfn2.

2024-01-24 | GSE235103 | GEO

Effect of EGFR activation on mouse chondrocytes

Project description:Effect of EGFR activation on mouse chondrocytes

| PRJNA450631 | ENA