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Effect of knockdown Aurora kinase A（AURKA） on gene expression in LX2 cells.

ABSTRACT: Effect of knockdown Aurora kinase A（AURKA） on gene expression in LX2 cells.

PROVIDER: PRJNA909202 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22547400_1.fastq.gz	Fastqsanger.gz
	SRR22547400_2.fastq.gz	Fastqsanger.gz
	SRR22547401_1.fastq.gz	Fastqsanger.gz
	SRR22547401_2.fastq.gz	Fastqsanger.gz
	SRR22547402_1.fastq.gz	Fastqsanger.gz

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Effect of knockdown Aurora kinase A（AURKA） on gene expression in LX2 cells.

Project description:We performed gene expression profiling analysis using data obtained from RNA-seq of LX2 cells treated with siRNA of AURKA or siNC.

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Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth

Project description:CXCR7, an atypical chemokine receptor (ACKR3), is up-regulated in NEPC, and its expression is associated with molecular markers of NEPC and cell proliferation. Transcriptomic analyses revealed a major role of CXCR7 in regulating downstream genes involved in the cell cycle and mitotic spindle. Membrane-bound CXCR7 is known to recruit β-arrestin (ARRB2), and the complex internalizes into clathrin-coated vesicles where they act as a scaffold for cytoplasmic kinase assembly and substrate activation. We identify Aurora Kinase A (AURKA) as a top candidate that is binding to and activated by CXCR7-ARRB2. Immunofluorescence confocal microscopy detected high-density CXCR7, ARRB2, and AURKA in the pericentrosomal area with focal staining of ARRB2 and ARUKA at centrosomes. Mass spectrometry showed that CXCR7 interacts with many proteins associated with intracellular vesicles, microtubules, and Golgi apparatus. CXCR7-ARRB2-containing vesicles traffic along the microtubules to the perinuclear Golgi apparatus, where CXCR7-ARRB2 interacts with AURKA to promote its activation and cell growth. Finally, we showed that pharmacological inhibitors of AURKA abolish CXCR7-driven tumor growth. Our study reveals CXCR7-mediated activation of AURKA and establishes CXCR7 and its downstream kinases as critical targets for therapeutic intervention in CRPC or NEPC patients.

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AURKA Expression in allogeneic HCT-recipients

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Aurka

Project description:Rattus norvegicus Aurka, aurora kinase A [Source:RGD Symbol;Acc:628895], is differentially expressed in 31 experiment(s);

| ENSRNOG00000004479 | ExpressionAtlas

Aurka

Project description:Rattus norvegicus Aurka, aurora kinase A [Source:RGD Symbol;Acc:628895], is expressed in 6 baseline experiment(s);

| ENSRNOG00000004479 | ExpressionAtlas

AURKA

Project description:Monodelphis domestica AURKA, aurora kinase A [Source:NCBI gene;Acc:100027920], is expressed in 1 baseline experiment(s);

| ENSMODG00000016435 | ExpressionAtlas

aurka

Project description:Xenopus tropicalis aurka, aurora kinase A [Source:Xenbase;Acc:XB-GENE-853082], is differentially expressed in 1 experiment(s);

| ENSXETG00000012032 | ExpressionAtlas

aurka

Project description:Xenopus tropicalis aurka, aurora kinase A [Source:Xenbase;Acc:XB-GENE-853082], is expressed in 1 baseline experiment(s);

| ENSXETG00000012032 | ExpressionAtlas

AURKA

Project description:Macaca mulatta AURKA, aurora kinase A [Source:VGNC Symbol;Acc:VGNC:70052], is expressed in 2 baseline experiment(s);

| ENSMMUG00000000070 | ExpressionAtlas

AURKA

Project description:Homo sapiens AURKA, aurora kinase A [Source:HGNC Symbol;Acc:HGNC:11393], is differentially expressed in 251 experiment(s);

| ENSG00000087586 | ExpressionAtlas