Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Metabolic dependencies of metastasis-initiating cells in breast cancer [RNA-seq]

ABSTRACT: Metabolic dependencies of metastasis-initiating cells in breast cancer [RNA-seq]

PROVIDER: PRJNA912218 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22739659_1.fastq.gz	Fastqsanger.gz
	SRR22739659_2.fastq.gz	Fastqsanger.gz
	SRR22739660_1.fastq.gz	Fastqsanger.gz
	SRR22739660_2.fastq.gz	Fastqsanger.gz
	SRR22739661_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Metabolic dependencies of metastasis-initiating cells in breast cancer

Project description:Metabolic dependencies of metastasis-initiating cells in breast cancer

| PRJNA912211 | ENA

Metabolic dependencies of metastasis-initiating cells in breast cancer [ChIP-Seq]

Project description:Metabolic dependencies of metastasis-initiating cells in breast cancer [ChIP-Seq]

| PRJNA989280 | ENA

Metabolic dependencies of metastasis-initiating cells in breast cancer [RNA-Seq 2]

Project description:Metabolic dependencies of metastasis-initiating cells in breast cancer [RNA-Seq 2]

| PRJNA989222 | ENA

Metabolic dependencies of metastasis-initiating cells in breast cancer [RNA-Seq 3]

Project description:Metabolic dependencies of metastasis-initiating cells in breast cancer [RNA-Seq 3]

| PRJNA989281 | ENA

Targeting Unique Metabolic Properties of Breast Tumor Initiating Cells

Project description:Bulk cancer cell populations are known to display distinct metabolic properties compared to their normal counterparts. However, relatively little is known about heterogeneity of metabolic properties within tumors. In this study we show that, analogous to some normal stem cells, breast tumor initiating cells (TICs, also called cancer stem cells) have distinct metabolic properties compared to non-tumorigenic cancer cells (NTCs). Transcriptome profiling using RNA-Seq revealed TICs under-express genes involved in mitochondrial oxidative phosphorylation and although TICs are relatively quiescent, they preferentially perform glycolysis over oxidative phosphorylation compared to NTCs. TICs contain fewer mitochondria and display lower expression and activity of pyruvate dehydrogenase (Pdh), a key regulator of oxidative phosphorylation. Metabolic reprogramming of TICs by pharmacologic activation of Pdh preferentially eliminates TICs in vitro and in vivo. Our findings reveal unique metabolic properties of TICs and indicate that metabolic reprogramming represents a promising strategy for targeting these cells. Examination transcriptome profiles for breast tumor initiating cells (TICs) and non-tumorigenic cells (NTCs)

2014-07-31 | E-GEOD-41286 | biostudies-arrayexpress

Metabolic dependencies of metastasis-initiating cells in breast cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-20 | GSE220992 | GEO

Targeting Unique Metabolic Properties of Breast Tumor Initiating Cells

2014-07-31 | GSE41286 | GEO

Metabolic dependencies of metastasis-initiating cells in breast cancer [RNA-seq]

Project description:We investigated gene expression changes in response to acetate treatment, which results in increased MIC-frequency, H3K27ac, and metastatic potential.

2023-09-20 | GSE220991 | GEO

Metabolic dependencies of metastasis-initiating cells in breast cancer [ChIP-Seq]

Project description:We investigated the changes in acetylation peaks on H3K27ac in cells in response to inhibitors that alter the activity of acetyl-coa generating enzymes

2023-09-20 | GSE236223 | GEO

Identification of ALDH1A3 as a viable therapeutic target in breast cancer metastasis-initiating cells

Project description:Identification of ALDH1A3 as a viable therapeutic target in breast cancer metastasis-initiating cells

| PRJNA575571 | ENA