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Next Generation Sequencing Facilitates Quantitative Analysis of the effects of compound 5D on ILC2 transcriptome

ABSTRACT: Next Generation Sequencing Facilitates Quantitative Analysis of the effects of compound 5D on ILC2 transcriptome

PROVIDER: PRJNA912261 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22743212.fastq.gz	Fastqsanger.gz
	SRR22743213.fastq.gz	Fastqsanger.gz
	SRR22743214.fastq.gz	Fastqsanger.gz
	SRR22743215.fastq.gz	Fastqsanger.gz

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Next Generation Sequencing Facilitates Quantitative Analysis of the effects of compound 5D on ILC2 transcriptome

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Project description:Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 cytokines that promote AHR and lung inflammation. In this study, we evaluated the protective role of PD-1 on the development of AHR by focusing on its capacity to regulate ILC2 activation. We find that PD-1 is highly inducible in pulmonary ILC2s and shapes their transcriptional activity, activation and metabolism. Our findings provide new insights regarding the mechanisms of ILC2 regulation, which could be used in innovative approaches for the treatment of allergic asthma.

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Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses - WT ILC2

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