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A hormone-activated mobile RNAi pathway defends plant stem cells from virus infection

ABSTRACT: A hormone-activated mobile RNAi pathway defends plant stem cells from virus infection

PROVIDER: PRJNA913128 | ENA |

REPOSITORIES: ENA

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A hormone-activated mobile RNAi pathway defends plant stem cells from virus infection

Project description:Study on the role of Arabidopsis thaliana RDR1 and other RNAi factors in the exclusion of RNA viruses from the shoot apical meristem stem cells

2023-10-09 | GSE221157 | GEO

Salicylic acid and RNA interference mediate antiviral immunity of plant stem cells (Previous preprint title: A hormone-activated mobile RNAi pathway defends plant stem cells from virus infection)

Project description:Salicylic acid and RNA interference mediate antiviral immunity of plant stem cells (Previous preprint title: A hormone-activated mobile RNAi pathway defends plant stem cells from virus infection)

| PRJNA1013591 | ENA

Salicylic acid and RNA interference mediate antiviral immunity of plant stem cells (Previous preprint title: A hormone-activated mobile RNAi pathway defends plant stem cells from virus infection)

Project description:Study on the role of Arabidopsis thaliana RDR1 and other RNAi factors in the exclusion of RNA viruses from the shoot apical meristem stem cells

2023-10-09 | GSE242499 | GEO

In planta dynamics, transport-biases and endogenous functions of mobile siRNAs in Arabidopsis

Project description:In RNA interference (RNAi), small-interfering (si)RNAs processed from double-stranded RNA guide ARGONAUTE(AGO) proteins to silence sequence-complementary RNA/DNA. Plant RNAi can propagate locally and systemically, but despite recent mechanistic advances, basic questions/hurdles remain unaddressed. For instance, RNAi is inferred to diffuse through plasmodesmata, yet how its dynamics in planta compares with that of established symplastic-diffusion markers remains unknown. Also unknown is why select siRNA species, or size-classes thereof, are recovered in RNAi-recipient tissues, yet only under some experimental settings. Finally, RNAi shootward movement in micro-grafted Arabidopsis necessary to study its presumptive transgenerational effects– has not been achieved thus far and endogenous functions of mobile RNAi remain scarcely documented. Focusing on non-amplified RNAi in Arabidopsis, we show here that (i) transgenic RNAi-movement, although symplasmic, only partially recapitulates the diffusion pattern of free GFP in planta, (ii) the presence/absence of specific AGOs in incipient/traversed/recipient tissues likely explains the apparent siRNA-selectivity observed during vascular movement, (iii) stress application allows endo-siRNA translocation against the shoot-to-root phloem flow, and (iv) mobile endo-siRNAs generated from a single inverted-repeat(IR) locus, have the potential to regulate hundreds of transcripts.

2021-10-07 | GSE112861 | GEO

Mobile PEAR transcription factors integrate hormone and miRNA cues to prime cambial growth

Project description:Mobile PEAR transcription factors integrate hormone and miRNA cues to prime cambial growth

| PRJNA474028 | ENA

Carnobacterium mobile

Project description:Carnobacterium mobile overview

| PRJNA520204 | ENA

[Mycoplasma] mobile

Project description:Mycoplasma mobile overview

| PRJNA36705 | ENA

Aminobacterium mobile

Project description:Aminobacterium mobile overview

| PRJNA195993 | ENA

Mobile PEAR transcription factors integrate hormone and miRNA cues to prime cambial growth

Project description:In addition to apical growth, plants undergo radial growth to increase girth, a particularly prominent feature in trees. During both apical and radial growth the phytohormones auxin and cytokinins form symmetries that govern further growth patterns. But whereas the gene regulatory networks interpreting the hormonal fields during apical growth are well established, such networks are not known for the radial growth. We show here that the initiation of radial growth occurs around early protophloem sieve element (PSE) cell files of the root procambial tissue in Arabidopsis. In this domain cytokinin signalling promotes expression of a pair of novel mobile transcription factors, PHLOEM EARLY DOF (PEAR1, PEAR2) and their four homologs (OBP2, DOF6, TMO6 and HCA2), collectively called PEAR proteins. The PEAR proteins form a short-range concentration gradient peaking at PSE and activating gene expression that promotes radial growth. The expression and function of PEAR proteins are antagonized by well-established polarity transcription factors, HD-ZIP III, whose expression is concentrated in the more internal domain of radially non-dividing procambial cells by the function of auxin and mobile miR165/166. The PEAR proteins locally promote transcription of their inhibitory HD-ZIP III genes, thereby establishing a negative feedback loop that forms a sharp boundary demarking the zone of cell divisions. Taken together, we have established a network, in which the PEAR - HD-ZIP III module integrates the spatial information of the hormonal domains and miRNA gradients during root procambial development, to provide a pre-pattern with actively dividing and more quiescent zones, thus priming radial growth.

2018-11-09 | GSE115183 | GEO

The role of intestinal microbiota in breast cancer treatment with hormone therapy: a pathway to new therapeutic options

Project description:Interventions: No interventions Observational study Primary outcome(s): The primary endpoint is microbiota composition before and during (after 6 – 12 weeks) systemic hormone therapy in relation to systemic estrogen and endoxifen levels in respectively the cohort treated with aromatase inhibitors and tamoxifen. Study Design: Open (masking not used), N/A , unknown, Parallel

| 20525 | ecrin-mdr-crc

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