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Effect of Rh(III) on gene expression in HeLa cell line

ABSTRACT: Effect of Rh(III) on gene expression in HeLa cell line

PROVIDER: PRJNA913434 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22797188_1.fastq.gz	Fastqsanger.gz
	SRR22797188_2.fastq.gz	Fastqsanger.gz
	SRR22797189_1.fastq.gz	Fastqsanger.gz
	SRR22797189_2.fastq.gz	Fastqsanger.gz
	SRR22797190_1.fastq.gz	Fastqsanger.gz

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Effect of Rh(III) on gene expression in HeLa cell line

Project description:We designed a highly emissive rhodium(III) complex ( Rh(III) complex) as the mtDNA intercalator. Rh(III) complex can specifically bind to mtDNA to cause the cytoplasmic release of mtDNA fragments to activate the cGAS-STING pathway. Moreover, Rh(III) complex activates the mitochondrial retrograde signaling by disturbing the key metabolites. Herein,we performed RNA-seq to illustrate the function of Rh(III) complex on HeLa cells. RNA-seq was performed on HeLa cells, which were treated by 1% DMSO or Rh(III) complex (1 uM, 6h), respectively.

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