Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Transcriptome of Quillaja saponaria

PROVIDER: PRJNA914309 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22829626_1.fastq.gz	Fastqsanger.gz
	SRR22829626_2.fastq.gz	Fastqsanger.gz
	SRR22829627_1.fastq.gz	Fastqsanger.gz
	SRR22829627_2.fastq.gz	Fastqsanger.gz
	SRR22829628_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Quillaja saponaria

Project description:Quillaja saponaria overview

| PRJNA488309 | ENA

Quillaja saponaria isolate:S10

Project description:Quillaja saponaria isolate:S10 Genome sequencing and assembly

| PRJNA914519 | ENA

Quillaja saponaria isolate:C | cultivar:MT

Project description:Chloroplast genome of the soap bark tree Quillaja saponaria

| PRJNA487056 | ENA

Project description:Transcriptome of Saponaria officinalis

| PRJNA1008697 | ENA

Microarray analysis of innate immune response induced by immunization with the adjuvant QS-21 in lymph node and muscle in mice.

Project description:The goal of this study was to identify the transcriptional mechanisms involved in the activation of the immune system by QS-21, a triterpene glycoside purified from the bark of Quillaja saponaria which has adjuvant activity in vivo. Saponins represent a promising class of vaccine adjuvant. Together with the TLR4-ligand MPL, QS-21 is part of the Adjuvant System AS01, a key component of the Malaria and Zoster candidate vaccines that display demonstrated clinical efficacy. However, the mechanism of action of QS-21 in this liposomal formulation is poorly understood. Upon intra-muscular immunisation, we observed that QS-21 rapidly accumulated in CD169+ resident macrophages of the draining lymph node where it elicited a local innate immune response. Depletion of these cells abrogated QS-21-mediated innate cell recruitment to the lymph node, dendritic cell (DC) phenotypic maturation as well as the adjuvant effect on T cell and antibody responses to co-administered antigens. DCs rather than lymph node-resident macrophages were directly involved in T cell priming by QS-21 as revealed by the decrease in antigen-specific T cell response in Batf3−/− mice. Further analysis showed that the adjuvant effect of QS-21 depended on the integration of Caspase-1 and MyD88 pathways, at least in part through the local release of HMGB1. Taken together, this work unravels the key role of lymph node sentinel macrophage in controlling the adjuvant effect of a molecule proven to improve vaccine response in humans

2016-12-06 | GSE90864 | GEO

Saponaria officinalis cultivar:Norfolk 2

Project description:Saponaria officinalis Norfolk 2 Transcriptome - Sa_off_leaf

| PRJNA1035542 | ENA

Saponaria officinalis

Project description:Saponaria officinalis overview

| PRJNA1082862 | ENA

The full-length Quillaja brasiliensis (Quillajaceae) reference transcriptome

Project description:The full-length Quillaja brasiliensis (Quillajaceae) reference transcriptome

| PRJEB58985 | ENA

Saponaria officinalis isolate:JIC

Project description:Saponaria officinalis isolate:JIC Genome sequencing