Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MicroRNA expression in KrasG12D+Tgfbr2-/- mouse pancreatic cancer

ABSTRACT: microRNA expression in KrasG12D+Tgfbr2-/- mouse pancreatic cancer

PROVIDER: PRJNA914322 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

microRNA expression in KrasG12D+Tgfbr2-/- mouse pancreatic cancer

Project description:comprehensive evaluation of microRNA expression in KrasG12D+Tgfbr2-/- mouse pancreatic cancer

2023-01-27 | GSE221449 | GEO

RRBS of pancreatic cancer cells derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele

Project description:Pancreatic adenocarcinoma (PDAC) is a lethal disease and it is the most common type of pancreatic cancer. Majority of the pancreatic cancers harbor alterations in the Kras gene. Currently there are no approved drugs that target Kras directly and it's downstream effect on the epigenome remains unknown. In this study, we investigated the epigenetic landscape of pancreatic cancer cells which harbor the inducible KrasG12D allele. We performed RNA-seq, ChIP-seq against 6 different histone marks, ATAC-seq and RRBS to assess the changes in the epigenome after oncogenic KrasG12D induction.

2021-09-06 | E-MTAB-10900 | biostudies-arrayexpress

Insulin receptor signaling in pancreatic acinar cells contributes to KrasG12D-driven cancer initiation in the context of diet-induced obesity

Project description:Phosphoproteomic analysis to elucidate whether high-fat diet induced hyperinsulinemia contributes to pancreatic cancer directly through insulin receptor (INSR) signaling in KrasG12D-expressing pancreatic acinar cells.

2023-10-19 | PXD033845 | Pride

RNA-seq of pancreatic cancer cells derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele

2021-09-06 | E-MTAB-10896 | biostudies-arrayexpress

ChIP-seq of pancreatic cancer cells derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele

2021-09-06 | E-MTAB-10901 | biostudies-arrayexpress

ATAC-seq of pancreatic cancer cells derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele

2021-09-19 | E-MTAB-10909 | biostudies-arrayexpress

Comparison of gene expression changes of pancreatic tissue from Ptf1aCre;KrasG12D and Ptf1aCre;KrasG12D;SnailKI/+ mice

Project description:Comparison of gene expression changes of pancreatic tissue from Ptf1aCre;KrasG12D and Ptf1aCre;KrasG12D;SnailKI/+ mice at the age of 1 month and 3 months.

2022-11-19 | E-MTAB-8174 | biostudies-arrayexpress

RNA sequencing of organoids isolated from pancreatic cancer mouse model KRASG12D; p53R172H; Ptf1a-Cre.

Project description:We studied the transcriptomics of pancreatic ductal adenocarcinoma (PDAC) and the role of a splicing factor called SF3B1 in this context. We generated mice that will develop PDAC via an inducible expression of KRASG12D; p53R172H specifically in the pancreas using a Ptf1a-Cre.

2017-01-09 | GSE93279 | GEO

Comparison of mRNA profiles of AGO2 sufficent and deficient pancreatic tissue in the LSL KRASG12D mouse model of pancreatic cancer

Project description:Purpose: The goals of this study are to compare NGS-derived transcripts to compare the expression of transcripts between AGO2 sufficent PDAC tissue and AGO2 deficient senescent PanINs in the mouse model Methods: mRNA profiles of 500 day-old AGO2+/+;KRASG12D;p48Cre and AGO2fl/fl;KRASG12D;p48Cre pancreatic tissue were generated in duplicates Results: mRNA transcripts were further analyzed using GSEA tools for mouse transcript quantitation

2020-03-31 | GSE147781 | GEO

RNA-seq of pancreatic cancer cells (1012 and 9805) derived from a genetically engineered mouse model, which harbor the inducible KrasG12D allele

2021-09-14 | E-MTAB-10897 | biostudies-arrayexpress