Project description:RNAseq across a time cours of meiosis of cells with and without Kar4p. The overexpression of either IME1 or both IME1 and RIM4 was used to determine how overexpression of the two genes functions to resuce the meiotic defect associated with the loss of Kar4p.

2023-02-01 | GSE221451 | GEO

Transcriptional profile associated with human oocyte meiotic maturation

Project description:Transcriptional profile associated with human oocyte meiotic maturation

| PRJNA639579 | ENA

Synchronized yeast meiotic culture timecourse

Project description:Synchronized yeast meiotic culture timecourse

| PRJNA354329 | ENA

Yeast meiotic transcriptom kar4 delete v. wild type

Project description:Transcriptional profiling of wild type and kar4 deletion yeast mutants across a meiotic time course. Including samples with IME1 and RIM4 overexpression

2023-02-01 | GSE220125 | GEO

Yeast meiotic transcriptional profile [Kfc1p mutant]

Project description:RNAseq across a time course of meiosis of cells with and without Kfc1p. The overexpression of either IME1 or both IME1 and RIM4 was used to determine how overexpression of the two genes functions to resuce the meiotic defect associated with the loss of Kar4p.

2023-02-01 | GSE222684 | GEO

Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast

Project description:The meiotic cohesin Rec8 is required for the stepwise segregation of chromosomes during the two rounds of meiotic division. By directly measuring chromosome compaction in living cells of the fission yeast Schizosaccharomyces pombe, we found an additional role for the meiotic cohesin in the compaction of chromosomes during meiotic prophase. In the absence of Rec8, chromosomes were decompacted relative to those of wild-type cells. Conversely, loss of the cohesin-associated protein Pds5 resulted in hyper-compaction. While this hyper-compaction requires Rec8, binding of Rec8 to chromatin was reduced in the absence of Pds5, indicating that Pds5 promotes chromosome association of Rec8. To explain these observations, we propose that meiotic prophase chromosomes are organized as chromatin loops emanating from a Rec8-containing axis; the absence of Rec8 disrupts the axis, resulting in disorganized chromosomes, whereas reduced Rec8 loading results in a longitudinally compacted axis with fewer attachment points and longer chromatin loops. Keywords: ChIP-chip analysis

2006-08-23 | GSE5284 | GEO