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H9c2 cell response after retinoic acid stimuli

ABSTRACT: H9c2 cell response after retinoic acid stimuli

PROVIDER: PRJNA915056 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22868000_1.fastq.gz	Fastqsanger.gz
	SRR22868000_2.fastq.gz	Fastqsanger.gz
	SRR22868001_1.fastq.gz	Fastqsanger.gz
	SRR22868001_2.fastq.gz	Fastqsanger.gz
	SRR22868002_1.fastq.gz	Fastqsanger.gz

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H9c2 cell response after retinoic acid stimuli

Project description:During culture, H9c2 cells acquire a myotubule phenotype where a critical component is the inclusion of retinoic acid (RA). The results from some authors on H9c2 suggested that thousands of genes respond to RA stimuli, while other authors report hundreds of genes responding to RA over different cell types. We investigated the response to RA in H9c2 cells controlling for culture time.

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PRAME induced inhibition of retinoic acid receptor signaling-mediated differentiation - a possible target for ATRA response in AML without t(15;17)

Project description:Purpose: In acute myeloid leukemia (AML) without retinoic acid receptor (RAR) rearrangement the effect of all-trans retinoic acid (ATRA) is still poorly understood despite an association of NPM1 mutation and ATRA response. Recently, PRAME (preferentially expressed antigen in melanoma) has been shown to be a dominant repressor of RAR-signaling. Experimental design: Thus, we further investigated ATRA response mechanisms, especially the impact of PRAME expression on ATRA-responsiveness by profiling gene expression in K562 cell lines. Results: Our data revealed a PRAME-expression associated gene pattern to be significantly enriched for genes involved in the retinoic acid metabolic process. In leukemia cell line models we could demonstrate that retinoic acid-regulated cell proliferation and differentiation are impacted by PRAME expression. Conclusions: PRAME seems to impair differentiation and to increase proliferation likely via blocking RAR-signaling, which might be reversed by ATRA.

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