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Translocation t(6 7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking [ACT-seq-BS]

ABSTRACT: Translocation t(6 7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking [ACT-seq-BS]

PROVIDER: PRJNA915959 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22893364_1.fastq.gz	Fastqsanger.gz
	SRR22893364_2.fastq.gz	Fastqsanger.gz
	SRR22893365_1.fastq.gz	Fastqsanger.gz
	SRR22893365_2.fastq.gz	Fastqsanger.gz

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Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking [ACT-seq-BS]

Project description:The leukemic cell line GDM-1 was established from a patient with acute myelomonoblastic leukemia [4]. GDM-1 cells carry a reciprocal translocation t(6;7)(q23;q36) juxtaposing the transcription factor (TF) gene motor neuron and pancreas homeobox 1 (MNX1, also designated HLXB9 or HB9) on chromosome 7 (chr7) to the locus of the transcriptional activator MYB on chr6. The translocation does not result in a fusion transcript but leads to aberrant activation of MNX1, suspected to be due to altered topologically associating domains, nuclear positioning or ectopic mechanisms. GDM-1 represents the only AML cell line overexpressing MNX1. Here we demonstrate that the interaction between the MNX1 promoter with a ‘hijacked’ enhancer from the MYB/AHI1 locus leads to ectopic activation of MNX1.

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