Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Phenotypic and Genotypic Analysis of Keratoconus

ABSTRACT: Phenotypic and Genotypic Analysis of Keratoconus

PROVIDER: PRJNA916337 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Phenotypic and Genotypic Analysis of Keratoconus

Project description:Phenotypic and Genotypic Analysis of Keratoconus

| PRJNA916336 | ENA

Phenotypic and genotypic AMR of Streptococcus uberis

Project description:Phenotypic and genotypic AMR of Streptococcus uberis

| PRJEB67942 | ENA

RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients

Project description:We compared the transcriptome of keratoconus and control epithelium using RNA-Seq. Epithelial tissues were obtained prior to surgery from keratoconus and myopia control patients, undergoing collagen cross-linking and photorefractive keratectomy, respectively. We identified major differences in keratoconus linked to cell-cell communication, cell signalling and cellular metabolism. The genes associated with the Hedgehog, Wnt and Notch1 signaling pathways were down-regulated in keratoconus.

2018-05-10 | GSE112155 | GEO

Single Cell Genotypic and Phenotypic Analysis of Measurable Residual Disease in Acute Myeloid Leukemia

Project description:Single Cell Genotypic and Phenotypic Analysis of Measurable Residual Disease in Acute Myeloid Leukemia

| PRJNA947747 | ENA

Single Cell Genotypic and Phenotypic Analysis of Measurable Residual Disease in Acute Myeloid Leukemia

Project description:Single Cell Genotypic and Phenotypic Analysis of Measurable Residual Disease in Acute Myeloid Leukemia

| PRJNA947748 | ENA

Phenotypic and genotypic stability in a preclinical model of renal cell carcinoma

Project description:Renal cell carcinomas are often resistant to conventional cytotoxic agents. Xenograft models are used for in vivo preclinical studies and drug development. The validity of these studies is highly dependent on the phenotypic and genotypic stability of the models. We evaluated the stability of six kidney tumors xenografted in nude/NMRI mice. We compared the initial sample (P0), 1st (P1) and 5th (P5) passages for the following criteria: histopathological analysis, immunohistochemistry for CK7, CD10, vimentin and p53, and DNA analysis with 10 microsatellites. We also performed CGH-array and we compared the sensitivity to sunitinib with tumor response in patients. The six xenografted tumors showed no difference between the morphology of the primary tumor and that of the xenografted tumor at P1 and P5 but we observed differences for CK7 expression in one case and for p53 expression in another. Out of 44 P0-P1-P5 groups with fully available microsatellite data, 29 (66%) showed no significant difference from P0 to P5 while 15 (34%) showed new or lost alleles. In CGH-array, genomic alterations at P5 were close to those already present in the initial tumor. We also observed similarity between the models and the patients for response to antiangiogenic treatment. We showed that the six xenograft models were phenotypically and genotypically stable across passages and showed similarity with response to treatment in patients.

2014-12-31 | GSE43810 | GEO

Phenotypic and genotypic characteristics of MSSA isolates responsible for infective endocarditis

Project description:Phenotypic and genotypic characteristics of MSSA isolates responsible for infective endocarditis

| PRJEB82234 | ENA

Study on m6A methylation modification of keratoconus

Project description:Transcriptional analysis of human keratoconus compared differentiated expression between normal and cone corneas. m6a modification plays an as yet unclear role in cone corneas, and here we aim to identify variations in m6a modification in cone corneas and the potential role it plays.

2023-08-01 | GSE181618 | GEO

Comparative transcriptome and network biology analyses demonstrate antiproliferative and hyperapoptotic phenotypes in human keratoconus corneas

Project description:Comparative transcriptome between Keratoconus and control corneas

2011-08-17 | E-MEXP-2777 | biostudies-arrayexpress

Differential gene expression profiles of corneal epithelium from Keratoconus patients

Project description:The gene expression profile of various cell signaling pathway associated genes were compared between the different clinical grades of keratoconus corneal epithelium, controls

2017-04-30 | GSE92935 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data