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A neural substrate for negative affect dictates female parental behaviour

ABSTRACT: A neural substrate for negative affect dictates female parental behaviour

PROVIDER: PRJNA917559 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22956152_1.fastq.gz	Fastqsanger.gz
	SRR22956152_2.fastq.gz	Fastqsanger.gz
	SRR22956153_1.fastq.gz	Fastqsanger.gz
	SRR22956153_2.fastq.gz	Fastqsanger.gz
	SRR22956154_1.fastq.gz	Fastqsanger.gz

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A neural substrate for negative affect dictates female parental behaviour

Project description:Parental behaviours are essential to secure survival and wellbeing of newborns. Concomitantly, parenting also limits negative affective states in adults, which emerge when the coping with neonatal distress becomes a challenge. Whether neural circuits that process negative affect orchestrate components of parental behaviours remains, however, unknown. Here, we identify functional and transcriptional signatures of parental behaviours in neurons of the negative emotion center lateral habenula receiving bed nucleus of the stria terminalis innervation (BNSTLHb). Calcium imaging and optogenetic manipulations reveal that LHb neurons of virgin female mice increase their activity in response to pup distress vocalization and are necessary for pup calls-driven aversive behaviours. Accordingly, LHb activity rises during the retrieval of a pup to a nest, a behaviour worsened by optogenetic LHb inactivation. Intersectional cell identification and transcriptional profiling associates the BNSTLHb neuronal population to parental behaviours and outlines gene expression in female virgins that is similar to mothers but divergent from non-parental virgin male mice. Accordingly, optogenetic activation and inactivation of the BNST-LHb pathway maximizes and suppresses, respectively, the parental behaviour. Finally, tracking and manipulating single BNSTLHb cell activity demonstrates specificity of this neuronal subset for encoding negative affect and pup retrieval, but not sociability amongst conspecifics. Thus, BNSTLHb cells are operational for female parenting, demonstrating that a negative affect neural circuit processes newborn distress signals and limits them through female parenting.

2023-01-04 | GSE222064 | GEO

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Project description:Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells [scRNA-Seq]

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Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells [ATAC-Seq]

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Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells [RNA-Seq 1]

Project description:Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells [RNA-Seq 1]

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Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells [RNA-Seq 2]

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Neurotranscriptomic changes associated with chick-directed parental care in adult non-reproductive Japanese quail

Project description:For many species, parental care critically affects offspring survival. But what drives animals to display parental behaviours towards young? In mammals, pregnancy‐induced physiological transformations seem key in preparing the neural circuits that lead towards attraction (and reduced‐aggression) to young. Beyond mammalian maternal behaviour, knowledge of the neural mechanisms that underlie young‐directed parental care is severely lacking. We took advantage of a domesticated bird species, the Japanese quail, for which parental behaviour towards chicks can be induced in virgin non‐ reproductive adults through a sensitization procedure, a process that is not effective in all animals. We used the variation in parental responses to study neural transcriptomic changes associated with the sensitization procedure itself and with the outcome of the procedure (i.e., presence of parental behaviours). We found differences in gene expression in the hypothalamus and bed nucleus of the stria terminalis, but not the nucleus taeniae. Two genes identified are of particular interest. One is neurotensin, previously only demonstrated to be causally associated with maternal care in mammals. The other one is urocortin 3, causally demonstrated to affect young‐directed neglect and aggression in mammals. Because our studies were conducted in animals that were reproductively quiescent, our results reflect core neural changes that may be associated with avian young‐directed care independently of extensive hormonal stimulation. Our work opens new avenues of research into understanding the neural basis of parental care in non‐placental species.

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Infant Pain Vs. Pain with Parental Suppression: Immediate and Enduring Impact on Brain, Pain and Affect

Project description:Infant Pain Vs. Pain with Parental Suppression: Immediate and Enduring Impact on Brain, Pain and Affect

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