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Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury [II]

ABSTRACT: Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury [II]

PROVIDER: PRJNA918733 | ENA |

REPOSITORIES: ENA

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Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

Project description:Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

| PRJNA918732 | ENA

Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury [I]

Project description:Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury [I]

| PRJNA895452 | ENA

Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury [I]

Project description:To investigate the transcriptomic differences between bone marrow mesenchymals stem cells and periosteal skeletal stem cells at steady state, and periosteal skeletal stem cells 72 hours after bone transplantation

2023-01-12 | GSE216824 | GEO

Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury [II]

Project description:To investigate the transcriptomic differences between bone marrow mesenchymals stem cells and periosteal skeletal stem cells at steady state, and graft bone marrow mesenchymal stem cells 5 months after transplantation

2023-01-12 | GSE222271 | GEO

Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-12 | GSE222272 | GEO

Comparative analysis of gene expression identifies distinct molecular signatures of bone marrow- and periosteal skeletal stem/progenitor cells

Project description:Genetic comparison between periosteal skeletal stem cells and bone marrow skeletal stem cells in mice

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RNPS1 inhibits excessive TNF/TNFR signaling to support hematopoiesis in mice

Project description:RNPS1 inhibits excessive TNF/TNFR signaling to support hematopoiesis in mice

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Inflammatory signals from fatty bone marrow support DNMT3a-driven clonal hematopoiesis (Dnmt3A KI heterozygote subset)

Project description:Inflammatory signals from fatty bone marrow support DNMT3a-driven clonal hematopoiesis (Dnmt3A KI heterozygote subset)

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Inflammatory signals from fatty bone marrow support DNMT3a-driven clonal hematopoiesis (wt/DNMT3A KI subset)

Project description:Inflammatory signals from fatty bone marrow support DNMT3a-driven clonal hematopoiesis (wt/DNMT3A KI subset)

| PRJEB59818 | ENA

Inflammatory signals from fatty bone marrow support DNMT3a-driven clonal hematopoiesis (wt/DNMT3A KI subset)

Project description:Accumulation of fatty bone marrow (FBM) is one of the key age related changes possibly influencing the blood system. While a link between obesity and cancer evolution has been reported it remains unknown whether FBM can modify the evolution of the early stages of leukemia and clonal hematopoiesis (CH). To address this question, we established different FBM mouse models in immunodeficient mice in whom we can study both mouse and human cells. We focused our studies on two FBM models: 1) after sublethal irradiation; 2) after castration; and in both we used an adipogenesis inhibitor as a control (PPARγ inhibitor). We transplanted both human and mice hematopoietic stem cells (HSCs) carrying DNMT3A mutations into immunodeficient mice with FBM. A significant increase in self-renewal was found when DNMT3AMut-HSCs were exposed to FBM. To better understand the mechanisms of the FBM-CH interaction, we performed single cell RNA-sequencing on HSPCs after FBM exposure in vivo. A 6-10 fold increase in DNMT3AMut-HSCs was observed under FBM conditions in comparison to normal bone marrow. Mutated HSCs from mice exposed to FBM exhibited an activated inflammatory signaling (IL-6 and IFNγ). Cytokine analysis of BM fluid and BM derived adipocytes grown in vitro demonstrated increased IL-6 levels under FBM conditions. Anti-IL-6 neutralizing antibodies significantly reduced the selective advantage of mice derived DNMT3AMut-HSCs exposed to FBM. Overall, paracrine FBM inflammatory signals promote DNMT3A-driven clonal hematopoiesis, which can be inhibited by blocking the IL-6 receptor.

2023-02-19 | E-MTAB-12614 | biostudies-arrayexpress

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