Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A Molecular Signature Defining Exercise Adaptation and In Vivo Reprogramming in Skeletal Muscle

ABSTRACT: A Molecular Signature Defining Exercise Adaptation and In Vivo Reprogramming in Skeletal Muscle

PROVIDER: PRJNA919032 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22999207_1.fastq.gz	Fastqsanger.gz
	SRR22999207_2.fastq.gz	Fastqsanger.gz
	SRR22999208_1.fastq.gz	Fastqsanger.gz
	SRR22999208_2.fastq.gz	Fastqsanger.gz
	SRR22999209_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

A Molecular Signature Defining Exercise Adaptation and In Vivo Reprogramming in Skeletal Muscle [RNA-seq]

Project description:A Molecular Signature Defining Exercise Adaptation and In Vivo Reprogramming in Skeletal Muscle [RNA-seq]

| PRJNA919022 | ENA

A Molecular Signature Defining Exercise Adaptation and In Vivo Reprogramming in Skeletal Muscle [BiSulfite-seq]

Project description:A Molecular Signature Defining Exercise Adaptation and In Vivo Reprogramming in Skeletal Muscle [BiSulfite-seq]

| PRJNA919034 | ENA

A Molecular Signature Defining Exercise Adaptation and In Vivo Reprogramming in Skeletal Muscle [RNA-seq]

Project description:Transcriptome comparison to elucidate the effects of exercise on molecular reprogramming in skeletal muscle tissue.

2023-12-01 | GSE222329 | GEO

Molecular control of endurance training adaptation in mouse skeletal muscle

Project description:Skeletal muscle has an enormous plastic potential to adapt to various external and internal perturbations. While morphological changes in endurance-trained muscles are well-described, the molecular underpinnings of training adaptation are poorly understood. We aimed at defining the molecular signature of a trained muscle and unraveling the training status- dependent responses to an acute bout of exercise. Our results reveal that even though at baseline, the transcriptomes of trained and untrained muscles are very similar, training status substantially affects the transcriptional response to an acute challenge, both quantitatively and qualitatively, in part mediated by epigenetic modifications. Furthermore, proteomic changes were elicited by different transcriptional modalities. Finally, transiently activated factors such as the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) are indispensable for normal training adaptation. Together, these results provide a molecular framework of the temporal and training status-dependent exercise response that defines muscle plasticity in training.

2023-06-19 | MSV000092203 | MassIVE

Genetic and Epigenetic Regulation of Skeletal Muscle Ribosome Biogenesis with Exercise

Project description:Ribosomes are the macromolecular engines of protein synthesis. Factors mediating ribosome biogenesis in skeletal muscle that facilitate adaptation to exercise are multi-factorial, but may be related to ribosomal DNA (rDNA) dosage and/or epigenetic modifications to rDNA. To investigate these possibilities, we conducted reduced representation bisulfite sequencing (RRBS) on skeletal muscle biopsies from human subjects before and after exercise and to detect differences in methylation patterns during exercise adaptation.

2021-07-13 | GSE162392 | GEO

A Molecular Signature Defining Exercise Adaptation and In Vivo Reprogramming in Skeletal Muscle [BiSulfite-seq]

Project description:Methylome comparison to elucidate the effects of myc on molecular reprogramming in skeletal muscle tissue.

2023-12-01 | GSE222330 | GEO

Transcriptional control of training adaptation in skeletal muscle

Project description:Skeletal muscle has an enormous plastic potential and adapts to various stimuli such as mechanical stress, nutrients and hormones. While morphological changes observed in endurance trained muscles are well described, the molecular underpinnings of training adaptation is poorly understood. Therefore, the aim of our study was to define the molecular signature of a trained muscle and unravel the transcriptional responses of untrained and trained muscles to an acute bout of endurance exercise. Our results reveal that even though at baseline, the transcriptome of trained and untrained muscles is very similar, training status substantially affects the transcriptional response to an acute challenge, both quantitatively and qualitatively. Therefore, we provide novel insights into the complex molecular processes that are induced in response to exercise in a temporal- and training status-dependent manner. In addition, our study reveals that the epigenetic landscape contributes to the transcriptional memory of a trained muscle.

2023-08-04 | GSE221210 | GEO

Epigenetic control of training adaptation in skeletal muscle

2023-08-04 | GSE221831 | GEO

Resistance Exercise Reverses Aging in Human Skeletal Muscle

Project description:Human aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia. We evaluated whether healthy aging was associated with a transcriptional profile reflecting mitochondrial impairment and whether resistance exercise could reverse this signature to that approximating a younger physiological age. Skeletal muscle biopsies from healthy older (N = 25) and younger (N = 26) adult men and women were compared using gene expression profiling, and a subset of these were related to measurements of muscle strength. 14 of the older adults had muscle samples taken before and after a six-month resistance exercise-training program. Before exercise training, older adults were 59% weaker than younger, but after six months of training in older adults, strength improved significantly (P<0.001) such that they were only 38% lower than young adults. As a consequence of age, we found 596 genes differentially expressed using a false discovery rate cut-off of 5%. Prior to the exercise training, the transcriptome profile showed a dramatic enrichment of genes associated with mitochondrial function with age. However, following exercise training the transcriptional signature of aging was markedly reversed back to that of younger levels for most genes that were affected by both age and exercise. We conclude that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed at the transcriptome level, following six months of resistance exercise training. Keywords: resistance exercise, muscle, aging

2007-07-16 | GSE8479 | GEO

CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise

Project description:CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise

| PRJNA1029906 | ENA