Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Profiling of cold exposure induced browning of white fat

ABSTRACT: Profiling of cold exposure induced browning of white fat

PROVIDER: PRJNA922060 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23022016_1.fastq.gz	Fastqsanger.gz
	SRR23022016_2.fastq.gz	Fastqsanger.gz
	SRR23022017_1.fastq.gz	Fastqsanger.gz
	SRR23022017_2.fastq.gz	Fastqsanger.gz
	SRR23022018_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Tanscriptome profiling of cold exposure induced browning of white fat

Project description:Tanscriptome profiling of cold exposure induced browning of white fat

| PRJNA922063 | ENA

Transcriptome profiling of cold exposure induced browning of white fat

Project description:Transcriptome profiling of cold exposure induced browning of white fat

| PRJNA689575 | ENA

Methylation profiling of cold exposure induced browning of white fat

Project description:Methylation profiling of cold exposure induced browning of white fat

| PRJNA922064 | ENA

RNA profiling to describe the transcriptional change during white fat browning, brown fat activity and inactivation

Project description:Enhancing brown fat activity and promoting white fat browning are attractive therapeutic strategies for obesity and its associated metabolic disorders. To provide a comprehensive picture of the regulatory network in these processes, we conducted a series of transcriptome studies by RNA-seq and quantified the mRNA and lncRNA changes during white fat browning induced by chronic cold exposure, beta-adrenergic agonist and intensive exercises, brown fat activation by acute cold exposure and inactivation by thermoneutrality.

2017-08-01 | GSE86338 | GEO

cAMP-MicroRNA-203-IFNγ Network Regulates Subcutaneous White Fat Browning and Glucose Tolerance

Project description:To determine the function of miR-203 in white fat browning upon cold exposure, we injected miR-203 inhibitors and negative control into inguinal white adipose tissue, followed by cold exposure (4oC) for 24 hours. Total RNA were harvested for RNA-seq.

2022-06-21 | GSE133142 | GEO

Transcriptome profiling of cold exposure induced browning of white fat

Project description:We revealed the common alterations and highlighted the differential effects between cold and β-AR agonists exposure on beige fat

2021-05-25 | GSE164219 | GEO

Cold-treated and Fasting-treated white-browning effect in inWAT

Project description:To investigate the white-browning effect in inguinal WAT tissue by cold-treated and fasting-treated

2022-11-09 | GSE217290 | GEO

BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

Project description:Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermogenic activation remains elusive. Here we found that BAF60a, a subunit of the SWI/SNF chromatin-remodeling complexes, serves an indispensible role in cold-induced thermogenesis in brown fat. BAF60a maintains chromatin accessibility for key thermogenic genes in close proximity to PPARg and EBF2 binding sites. Surprisingly, fat-specific BAF60a inactivation triggers more pronounced browning of inguinal white adipose tissue that is linked to induction of MC2R, a receptor for the pituitary hormone ACTH. Elevated MC2R expression sensitizes adipocytes and BAF60a-deficient adipose tissue to thermogenic activation in response to ACTH stimulation. These observations reveal an unexpected dichotomous role of BAF60a-mediated chromatin remodeling in transcriptional control of brown and beige gene programs and illustrate a pituitary-adipose signaling axis in the control of thermogenesis.

2020-02-20 | GSE128747 | GEO

BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

Project description:BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

| PRJNA528758 | ENA

Methylation profiling of cold exposure induced browning of white fat

Project description:We set two groups of 2-month-old C57BL6/J male mice at either thermoneutral temperature of 30℃ or under cold stimulation at 4℃ for one week. To identify events vital to beige fat activation, we performed MeRIP-seq using mice subcutaneous adipose tissue (iWAT) and focused on differentially-expressed genes characterized significant upregulation.

2023-08-20 | GSE222425 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data