Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Gram-negative bacilli sequencing

PROVIDER: PRJNA922195 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23029200_1.fastq.gz	Fastqsanger.gz
	SRR23029200_2.fastq.gz	Fastqsanger.gz
	SRR23029201_1.fastq.gz	Fastqsanger.gz
	SRR23029201_2.fastq.gz	Fastqsanger.gz
	SRR23029202_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 150

Similar Datasets

Gram negative bacilli

Project description:Gram negative bacilli Genome sequencing

| PRJNA353060 | ENA

Project description:Gram negative bacilli Genome sequencing and assembly

| PRJNA350603 | ENA

Project description:Glucose-nonfermentative gram-negative bacilli genomes

| PRJNA647677 | ENA

Gram negative Bacilli

Project description:Characterization of carbapenemase-producing Gram negative Bacilli Assembly

| PRJNA391501 | ENA

Project description:Collection of multiresistant Gram negative bacilli of clinical origin

| PRJNA1101420 | ENA

Gram-negative bacilli

Project description:Metagenomes containing gram-negative bacilli from positive blood culture broths

| PRJNA877287 | ENA

IBR1: A Novel Endogenous dsRNA Binding to the Helicase Domain of IFIH1 and Its Role in LPS-induced IFIH1 Activation and Macrophage M1 Polarization in ARDS [ATAC, ChIP]

Project description:Uncontrolled inflammatory responses driven by macrophages and monocytes play a crucial role in perpetuating lung injury and the severity of acute respiratory distress syndrome (ARDS). Previous studies have identified IFIH1 as a key regulator of macrophage M1 polarization in pneumonia-induced ARDS. IFIH1 is a cytosolic receptor responsible for recognizing viral double-stranded RNA (dsRNA) and activating inflammatory and antiviral signaling pathways. Interestingly, our observations indicate that IFIH1 can also be activated by lipopolysaccharide (LPS), a component of bacterial cell walls. However, the precise molecular mechanism underlying LPS-induced IFIH1 activation remains unclear. In our preliminary investigations, we have discovered a novel transcript, named IFIH1-binding RNA1 (IBR1), which is upregulated by LPS and gram-negative bacilli in monocytes and macrophages. We have confirmed that IBR1 interacts with the IFIH1 protein, forming a complex. Further experiments have revealed that IBR1, acting as an endogenous dsRNA, binds to the helicase domain of IFIH1 due to its local double-stranded structure. This specific interaction serves as the underlying molecular mechanism responsible for LPS-induced IFIH1 activation and subsequent macrophage M1 polarization in ARDS. Importantly, our observations indicate a significant upregulation of IBR1 expression in ARDS patients with gram-negative bacilli-induced pneumonia. Understanding the molecular mechanisms driving IFIH1 activation and macrophage M1 polarization in ARDS is of great importance for developing new therapeutic strategies to alleviate lung inflammation and improve patient outcomes. Further research is warranted to elucidate the precise roles of IBR1 and its potential as a therapeutic target in the management of ARDS.

2024-09-05 | GSE247176 | GEO

Klebsiella pneumoniae strain:HA3pKp

Project description:Study of KPC-producing Gram-Negative Bacilli (KPC-GNB) strains from one inpatient during hospitalization

| PRJNA845909 | ENA

Project description:SSI-Gram Negative

| PRJNA1117753 | ENA

Bacteria

Project description:Gram-negative Pathogen Genome Sequencing

| PRJNA261239 | ENA