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Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans [scRNA-Seq]

ABSTRACT: Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans [scRNA-Seq]

PROVIDER: PRJNA923706 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23078772_1.fastq.gz	Fastqsanger.gz
	SRR23078772_2.fastq.gz	Fastqsanger.gz
	SRR23078773_1.fastq.gz	Fastqsanger.gz
	SRR23078773_2.fastq.gz	Fastqsanger.gz
	SRR23078774_1.fastq.gz	Fastqsanger.gz

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Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

Project description:Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

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Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans [Rep-Seq]

Project description:Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans [Rep-Seq]

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Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

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Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans [scRNA-Seq]

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Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans [Rep-Seq]

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CHD7 promotes anti-viral short-lived effector CD8+ T cells

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Effector CD8 T cells dedifferentiate into long-lived memory cells

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A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans.

Project description:Seasonal influenza vaccination elicits hemagglutinin (HA)-specific memory B (Bmem) cells, and although multiple Bmem cell populations have been characterized, considerable heterogeneity exists. We found that HA-specific human Bmem cells differed in the expression of surface marker FcRL5 and transcriptional factor T-bet. FcRL5+T-bet+ Bmem cells were transcriptionally similar to effector-like memory cells, while T-betnegFcRL5neg Bmem cells exhibited stem-like central memory properties. FcRL5+ Bmem cells did not express plasma-cell-commitment factors but did express transcriptional, epigenetic, metabolic, and functional programs that poised these cells for antibody production. Accordingly, HA+ T-bet+ Bmem cells at day 7 post-vaccination expressed intracellular immunoglobulin, and tonsil-derived FcRL5+ Bmem cells differentiated more rapidly into antibody-secreting cells (ASCs) in vitro. The T-bet+ Bmem cell response positively correlated with long-lived humoral immunity, and clonotypes from T-bet+ Bmem cells were represented in the secondary ASC response to repeat vaccination, suggesting that this effector-like population predicts influenza vaccine durability and recall potential.

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Clinical study on the plasma and urine proteomics and antibody titers after COVID-19 vaccination

Project description:To find baseline markers that accurately predict vaccine reactivity and evaluate the correlation between baseline blood and urine proteomics and antibody titers after COVID-19 vaccination.

2023-11-09 | PXD036380 |

KLRG1+ Memory CD8 T cells Combine Properties of Short-lived Effectors and Long-lived Memory

Project description:CD8 effector T cells with a CD127hi KLRG1- phenotype are considered precursors to the long-lived memory pool, while KLRG1+ CD127low cells are viewed as short-lived effectors. Nevertheless, we and others have shown that a KLRG1+ CD127low population persists into the memory phase and that these T cells (termed long-lived effector cells or LLEC) display robust protective function during acute re-challenge with bacteria or viruses. Whether these T cells represent a true memory population or are instead a remnant effector cell population that failed to undergo initial contraction has remained unclear. Here, we show that LLEC from mice express a distinct phenotypic and transcriptional signature that shares characteristics of both early effectors and long-lived memory cells. Furthermore, we find that LLEC are exclusively derived from day 12 KLRG1+ effector cells. Our work challenges the concept that the KLRG1+ CD127low population is dominated by short-lived cells and shows that KLRG1 downregulation is not a prerequisite to become a long-lived protective memory T cell.

2020-08-26 | GSE152841 | GEO

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