Project description:To test whether human in vitro primed Th9 cells recapitulate the core pathogenic Th2 cell phenotype, we differentiated naïve T cells into Th1 (IL-12), Th2 (IL-4), Th9 (IL-4+TGF-β), and iTreg (TGF-β). After 7 days transcriptomic profiling by bulk RNA-seq was performed.

2022-10-31 | E-MTAB-12199 | biostudies-arrayexpress

RNA-seq of in vitro differentiated naïve and Th9 cells

Project description:RNA-seq of in vitro differentiated naïve and Th9 cells

| PRJNA923819 | ENA

ChIP-seq of in vitro differentiated naïve and Th9 cells

Project description:ChIP-seq of in vitro differentiated naïve and Th9 cells

| PRJNA923820 | ENA

RNA-seq of in vitro differentiated naïve and Th9 cells

Project description:To investigate changes in gene expression over time, we differentiated Th9 cells in vitro from naïve T cells from human and murine sources, and followed them over an extended time course, during which they gained and then lost capacity for IL-9 production We then performed gene expression profiling analysis using data obtained from RNA-seq in cells from 2 different human donors and from 2 mice at 4 time points.

2023-04-28 | GSE222909 | GEO

ChIP-seq of in vitro differentiated naïve and Th9 cells

Project description:To investigate changes in chromatin accessibility over time, we differentiated Th9 cells in vitro from naïve T cells from human and murine sources, and followed them over an extended time course, during which they gained and then lost capacity for IL-9 production We then performed Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for histone modifications H3K4me1, K3K4me3, and H3K27Ac in cells from 2 different human donors and from 2 mice at 4 time points.

2023-04-28 | GSE222908 | GEO

Transcriptional modifications driven by STING activation in polarizing TH1 and Th9 cells

Project description:We assessed the global transcriptional changes driven by STING activation with the cyclic dinucleotide 2'3'-cGAMP TH1 and TH9 cells polarized in vitro for 16h and 48h. Our data indicated that STING activation led to an upregulation of Type I Interferon, Interferon Stimulated Genes and pro-inflammatory molecule production that was maintained over time. Furthermore, not only STING activation enhanced the transcription of TH1 and TH9 main effector cytokines (respectively Ifng and Il9) but they also also globally enhanced their differentiation programs.

2022-02-18 | GSE147300 | GEO

FoxO4 ChIP-Seq profiles of WT differentiated TH1 cells

Project description:FoxO4 ChIP-Seq profiles of WT differentiated TH1 cells

| PRJNA549721 | ENA

The role of fatty acid metabolism on Th9 cells differentiation

Project description:T helper 9 cells (Th9) are interleukin 9 (IL-9)–producing cells that have diverse functions ranging from anti-tumor immune responses to driving allergic inflammation. Th9 cells differentiate from naïve CD4+ T cells in the presence of IL-4 and transforming growth factor-beta (TGF-β). In this reports, we have found that suppression of fatty acid biosynthesis increased IL-9 production in murine and human Th9 cells. This dataset include a set of data showing the effects of suppression of fatty acid synthesis on gene expression, chromatin remodelling and histone modifications in Th9 cells as analyzed by RNA-seq, ATAC-seq and ChIP-seq, respectively.

2024-09-10 | GSE275438 | GEO

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