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Diversity of cyanobacteria from Parsurameswara stone monument

ABSTRACT: Diversity of cyanobacteria from Parsurameswara stone monument Metagenome

PROVIDER: PRJNA924525 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23282320_1.fastq.gz	Fastqsanger.gz
	SRR23282320_2.fastq.gz	Fastqsanger.gz

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Polarization profiling of renal macrophages in stone model mice

Project description:We recently reported elimination of renal crystals and migration of macrophages (MM-OM-^F) around crystals in hyperoxaluric mice, suggesting MM-OM-^Fs might eliminate crystals. MM-OM-^Fs are of 2 phenotypes: inflammatory (M1) and anti-inflammatory (M2). Because M2MM-OM-^Fs are considered to be involved in tissue repair and regeneration, we focused attention on their suppressive role in renal crystal formation. Hence, we investigated the gene array profiling of renal macrophages in stone model mice and CSF-1-deficient stone model mice. B6C3Fe a/a-Csf1op/J wild type/homozygous mice were admistered 80mg/kg gyyoxylate (GOX) for 6days, then the kidneys were extracted and sorted CD11b+/CD11c+ macrophages using autoMACS. The gene expression of WT- and op/op-macrophages were investigated using bone marrow derived M1/M2 macrophages as controls.

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