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ABSTRACT: Hyperammonemia syndrome in solid organ transplant recipients due to Mycoplasma hominis derived from a single donor

PROVIDER: PRJNA924736 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23098029_1.fastq.gz	Fastqsanger.gz
	SRR23098029_2.fastq.gz	Fastqsanger.gz
	SRR23098030_1.fastq.gz	Fastqsanger.gz
	SRR23098030_2.fastq.gz	Fastqsanger.gz
	SRR23098031_1.fastq.gz	Fastqsanger.gz

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Donor-derived Mycoplasma hominis infection

Project description:Donor-derived Mycoplasma hominis and a cluster of M. hominis cases in solid organ transplant recipients

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The Gut Microbiome of liver transplant recipients Ã¢Â€Â“ Cross-sectional + Longitudinal (renal and liver)

Project description:TransplantLines is designed as a single-center, prospective cohort study and biobank including all different types of solid organ transplant recipients as well as living organ donors. In the TransplantLines gut microbiome study the gut microbiome of solid organ transplant recipients is characterized and linked to clinical phenotypes. This batch contains the cross-sectional data from liver transplant recipients and longitudinal data from renal and liver transplant recipients.

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The Gut Microbiome of renal transplant recipients Ã¢Â€Â“ Cross-sectional

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Gene expression in donor kidney biopsies prior to kidney transplantation

Project description:Donor organ shortage, growing waiting lists and organ discard rates are key problems in kidney transplantation. Donor organ quality is a critical factor determining post-transplant graft outcomes. However, organ quality is difficult to predict. Balancing the use of marginal donors without affecting outcomes is a main issue in the transplant field. The decision of acceptance of a kidney organ for transplantation is mainly based on donor organ biopsy findings, even though there are recognized limitations. The lack of better measures of organ quality at the time of transplantation as a predictor of performance graft outcome is a serious clinical challenge. Herein, we propose the use of a limited set of genes that captures intrinsic biology of kidney donor organs to improve available scoring systems. We studied gene expression in 192 deceased donor kidney biopsies and evaluated short-term outcomes which included delayed graft function and eGFR (high versus low) at 24 months for 168 kidney transplant recipients.

2022-06-13 | GSE147451 | GEO

Multi-omics of Bladder Cancers of Solid Organ Transplant Recipients

Project description:Multi-omics of Bladder Cancers of Solid Organ Transplant Recipients

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Multi-omics of Bladder Cancers of Solid Organ Transplant Recipients

Project description:Multi-omics of Bladder Cancers of Solid Organ Transplant Recipients

| PRJNA865855 | ENA

Project description:Whole genome profiling of lung microbiome in solid organ transplant recipients

| PRJNA806679 | ENA

4f116e53-e722-4a09-ad23-6833dda7688a - samples

Project description:The TransplantLines Gut Microbiome study includes raw data generated by shotgun metagenomic sequencing of fecal samples of solid organ transplant recipients and basic phenotypes (age and sex, BMI).

| EGAD00001008907 | EGA

Cell wall-deficient Mycoplasma hominis represses biofilm formation of uropathogenic Escherichia coli.

Project description:The features of Mycoplasma in human organ such lung and urinary tract are enigmatic. Here, the role of M. hominis in regard to biofilm formation of uropathogenic Escherichia coli (UPEC) strain CFT073 was investigated. Although M. hominis were inferred to not impact on UPEC bacterial fitness including growth and productions of signaling molecules as autoinducer-2 (AI-2) and indole, we found that the presence of M. hominis dramatically decreased biofilm formation of UPEC CFT073 as well as slightly repressed attachment and cytotoxicity of that. Importantly, this activity was observed on UPEC strain specifically, not enterohemorrhagic E. coli (EHEC) strain that exists on intestine. Whole-transcriptome profiling and quantitative real-time polymerase chain reaction (qRT-PCR) analysis revealed PhoPQ system and anti-termination protein (encoded by ybcQ) participates on the reduction of biofilm formation by M. hominis (corroborated by qRT-PCR). Furthermore, collaborating with previous report that toxin-antitoxin (TA) system involved in biofilm formation, M. hominis increased on the transcriptions of toxin genes including hha (toxin gene in Hha-TomB TA system) and pasT (toxin part in PasT-PasI TA system). Hence, we propose that one possible role of M. hominis is to influence bacterial biofilm formation in urinary tract. Only fourteen genes were induced (2.5-fold) by the presence of M. hominis in Uropathogenic Escherichia coli (UPEC) biofilm cells. Among upregulated genes, ybcQ (encodes anti-termination protein Q homolog) and phoP/phoQ (encode DNA-binding response regulators in two-component regulatory system), were induced by the presence of M. hominis. Two-condition experiment, UPEC CFT073 alone vs. UPEC CFT073 with Mycoplasma hominis PG21 (10^5 ccu/ml). For preparing the total RNA, UPEC CFT073 cells were grown at 37Â°C in biofilm cells on glass wool with or without M. hominis for 24 h.

2016-01-08 | E-GEOD-43376 | biostudies-arrayexpress

Mycoplasma hominis infection in renal transplant recipients

Project description:Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole genome sequencing

| PRJEB40931 | ENA

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