Project description:To study the role of HtrA2/Omi S400 phosphorylation, we generated knock in mice with HtrA2/Omi S400D mutation which mimics constitutive S400 phosphorylation of HtrA2/Omi.
Project description:RATIONALE: Studying the genes expressed in samples of tissue from patients with cancer may help doctors identify biomarkers related to cancer.
PURPOSE: This laboratory study is using gene expression profiling to evaluate normal tissue and tumor tissue from patients with colon cancer that has spread to the liver, lungs, or peritoneum.
Project description:The target of this project is to investigate the effect of ACOX1 knockout in liver Gene expression profiling analysis were performed using data obtained from RNA-seq of two genotypes mice liver
Project description:Gene expression profiling was carried out in two liver tumors and one normal liver isolated from β2SP+/-; SMAD3+/- mice, and one normal liver isolated from wild type mouse. Whole-transcriptome sequencing of these 4 liver tissues.