Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Autonomous transposons tune their sequences to ensure somatic suppression [polyA_S2]

ABSTRACT: Autonomous transposons tune their sequences to ensure somatic suppression [polyA_S2]

PROVIDER: PRJNA925494 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23125333_1.fastq.gz	Fastqsanger.gz
	SRR23125333_2.fastq.gz	Fastqsanger.gz
	SRR23125334_1.fastq.gz	Fastqsanger.gz
	SRR23125334_2.fastq.gz	Fastqsanger.gz
	SRR23125335_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Autonomous transposons tune their sequences to ensure somatic suppression.

Project description:Autonomous transposons tune their sequences to ensure somatic suppression.

| PRJNA925489 | ENA

Autonomous transposons tune their sequences to ensure somatic suppression [polyA_3T3]

Project description:Autonomous transposons tune their sequences to ensure somatic suppression [polyA_3T3]

| PRJNA925491 | ENA

Autonomous transposons tune their sequences to ensure somatic suppression [totalRNA_HEK293_fractionation]

Project description:Autonomous transposons tune their sequences to ensure somatic suppression [totalRNA_HEK293_fractionation]

| PRJNA1024427 | ENA

Autonomous transposons tune their sequences to ensure somatic suppression [polyA_HEK293]

Project description:Autonomous transposons tune their sequences to ensure somatic suppression [polyA_HEK293]

| PRJNA925492 | ENA

Autonomous transposons tune their sequences to ensure somatic suppression [polyA_HCT116]

Project description:Autonomous transposons tune their sequences to ensure somatic suppression [polyA_HCT116]

| PRJNA1024424 | ENA

Autonomous transposons tune their sequences to ensure somatic suppression [FLASH]

Project description:Autonomous transposons tune their sequences to ensure somatic suppression [FLASH]

| PRJNA925490 | ENA

Autonomous transposons tune their sequences to ensure somatic suppression [SAFKD_1H4_DHX9_FLASH]

Project description:Autonomous transposons tune their sequences to ensure somatic suppression [SAFKD_1H4_DHX9_FLASH]

| PRJNA1024416 | ENA

Autonomous transposons tune their sequences to ensure somatic suppression [directRNA_HEK293]

Project description:Autonomous transposons tune their sequences to ensure somatic suppression [directRNA_HEK293]

| PRJNA1024417 | ENA

Autonomous transposons tune their sequences to ensure somatic suppression [polyA_HeLa]

Project description:Autonomous transposons tune their sequences to ensure somatic suppression [polyA_HeLa]

| PRJNA925493 | ENA

Autonomous transposons tune their sequences to ensure somatic suppression [FLASH]

Project description:Transposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-mRNA synthesis, intronic TEs are transcribed along with their host genes but rarely contribute to the final mRNA product as they are spliced out together with the intron and rapidly degraded. Paradoxically, TEs are an abundant source of RNA-processing signals through which they can create new introns (Huff et al. 2016), and functional (Cosby et al. 2021) or non-functional chimeric transcripts (Clayton et al. 2020). The rarity of these events impliesy the existence of a resilient splicing code that is able to suppress TE-exonization without compromising host pre-mRNA processing. Here we show that SAFB proteins play a unique dual role in defence against TEs by preventing retrotransposition of L1 elements as well as their exonization when they land into genes by coating their adenosine-rich RNA. The suppressive activity of SAFB extends to neuro-, muscle- and testis-specific giant protein-coding cassette exons of ANK3, MAP4 and CLIP1, nested genes as well as Tigger DNA transposons, which are all enriched with adenosine/purine-rich sequences that act as splicing-enhancers in SAFB depleted cells. In mice and flies, SAFB additionally suppresses LTR/ERV elements, which are active in mice and flies, but no longer in humans. Splicing events suppressed by SAFB in somatic cells are activated in the testis, coinciding with low SAFB expression in post-meiotic spermatids. Reminiscent of the division of labour between innate and adaptive immune systems that fight external pathogens, our results uncover SAFB proteins as an RNA-based, pattern-guided, non-adaptive defence system against TEs in the soma, complementing the RNA-based, adaptive Piwi-piRNA pathway of the germline.

2024-01-08 | GSE223253 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data