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Transcriptomic analysis of SEFA-6179 treatment in preterm piglets receiving parenteral nutrition

ABSTRACT: Transcriptomic analysis of SEFA-6179 treatment in preterm piglets receiving parenteral nutrition

PROVIDER: PRJNA925851 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23149224_1.fastq.gz	Fastqsanger.gz
	SRR23149224_2.fastq.gz	Fastqsanger.gz
	SRR23149225_1.fastq.gz	Fastqsanger.gz
	SRR23149225_2.fastq.gz	Fastqsanger.gz
	SRR23149226_1.fastq.gz	Fastqsanger.gz

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Transcriptomic analysis of SEFA-6179 treatment in preterm piglets receiving parenteral nutrition

Project description:Preterm Yorkshire piglets were provided parenteral nutrition for 14 days, receiving treatment with SEFA-6179 or a medium chain triglyceride vehicle control. At the end of 14 days, MCT piglets developed cholestasis and histologic liver injury.

2023-06-03 | GSE223347 | GEO

Transcriptomic analysis of early IFALD in preterm piglets receiving parenteral nutrition

Project description:Preterm Yorkshire piglets were provided parenteral nutrition for 14 days and developed cholestasis and histologic liver injury. Bottle-fed age-matched controls were provided sow milk replacer every 2-3 hours for 14 days.

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Transcriptomic analysis of early IFALD in preterm piglets receiving parenteral nutrition

Project description:Transcriptomic analysis of early IFALD in preterm piglets receiving parenteral nutrition

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Neonatal antibotic prophylaxis modulates intestinal immunity and prevents necrotizing enterocolitis in preterm neonates

Project description:Caesarean-delivered preterm pigs were fed 3 d of parenteral nutrition followed by 2 d of enteral formula feeding. Antibiotics (n=11) or control saline (n=13) were given twice daily from birth to tissue collection at d 5. NEC-lesions and intestinal structure, function, microbiology and immunity markers were recorded. We used Affymetrix microarrays to investigate gene expression in intestinal tissues of preterm piglets treated with antibiotics or control saline. Twenty-four preterm piglets were delivered by caesarean section on day 105 of gestation from two healthy sows. All piglets were initially provided with parenteral nutrition via a vascular catheter, combined with small amounts of minimal enteral nutrition. On day three, all parenteral nutrition was stopped and total enteral nutrition was given through an oro-gastric feeding tube. Piglets were allocated into controls ( n=13) and an intervention group receiving oral and systemic broad-spectrum antibiotics ( n=11). To assure high systemic and intra luminal MIC values antibiotics were given both orally and intramuscularly. All antibiotics were given directly after feeding with an oral bolus and control pigs were given corresponding amounts of saline. On day five, all piglets were euthanized, and small intestinal tissue collected.

2013-08-21 | E-GEOD-48125 | biostudies-arrayexpress

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RNA-sequencing identifies novel transcriptomic signatures in parenteral nutrition-associated liver disease

Project description:RNA-sequencing in liver from control and parenteral nutrition-associated liver disease (PNALD) rats

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Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures

Project description:Parenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication for enteral feeding and a need for nutritional therapy. When PN is the only energy source in patients, it is defined as total parenteral nutrition (TPN). TPN is a life-saving approach for different patient populations, both in infants and adults. However, despite numerous benefits, TPN can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. IFALD pathogenesis is complex, depending on the TPN components as well as on the patient’s medical conditions. Despite numerous animal studies and clinical observations, the molecular mechanisms driving IFALD remain largely unknown. The present study was set up to elucidate the mechanisms underlying IFALD. For this purpose, human liver spheroid co-cultures were treated with TPN mixture followed by RNA sequencing analysis. It was found that prolonged exposure to TPN substantially changes the transcriptome profile of liver spheroids and affects multiple metabolic and signaling pathways contributing to liver injury.

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