MiRNA profiles of EVs released from menstrual blood-derived stem cells
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ABSTRACT:
PROVIDER: PRJNA926662 | ENA |
REPOSITORIES: ENA
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Project description:To identify specific miRNAs carried by MenSC-EVs, and explore their crucial roles in MenSC-EV-based improvement of inflammatory diseases.
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Project description:Mesenchymal stromal cells (MSCs) have been shown to exert their therapeutic effects through the secretion of various paracrine factors, including extracellular vesicles (EVs). These EVs are now being developed as a promising alternative to cell-based therapies. Menstrual blood-derived stromal cells (MenSCs) are a type of MSC that have emerged as a innovative source due to their immunomodulatory and regenerative properties. Additionally, new strategies of cell priming could potentially alter the concentration and cargo of released EVs, leading to modifications in their biological properties. In this study, we aimed to characterize the EVs released by MenSCs and to compare their therapeutic potential under three different preconditioning conditions (proinflammatory stimuli, physioxia, and acute hypoxia).
2023-04-05 | MSV000091644 | MassIVE
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2022-02-15 | E-MTAB-11417 | biostudies-arrayexpress
Project description:To investigated dysregulated miRNAs in human MDS patients, we performed miRNA-sequencing (miRNA-seq) of serum EVs from 38 MDS patients and 8 healthy subjects. The miRNA profile in EVs from MDS patients was distinctly clustered from that in healthy individuals. In addition, the miRNAs significantly upregulated in the MDS group target pathways linked to cell survival, proliferation, and MSC differentiation, indicating that they have remarkably similar properties to miRNAs in murine EVs from MDS cells. These results suggest that miRNAs play an essential role in the MSC impairment observed in MDS.
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Project description:Influenza is a major cause of human disease and mortality and a key cause of exacerbation in chronic disease like COPD. Recent studies have shown that airway epithelial cells, the primary target of influenza, release lipid bilayer particles known as Extracelluar vesicles (EVs) which contain biological molecules such as micro-RNA (miRNA). Emerging evidence suggests that these small non-coding RNA molecules are selectively packaged into EVs and can regulate recipient cell gene expression including major pathways involved in inflammation and fibrosis. Further understanding the role of EVs and their miRNA cargo in cellular communication in response to infection may identify biomarkers of disease or lead to novel theraputics. This study utilised a 3D model of IAV infection to explore the impact of IAV on the miRNA profile of EVs released from bronchial epithelial cells in vitro. Infection with IAV at 3.6 x 106 IU/ml for 24 hours was determined to be a suitable condition for EV analyses due to the detection of significant upregulation of anti-viral genes without high levels of cell death or loss of barrier integrity.
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Project description:To identify the mechanism by which miRNAs in EVs derived from MDS cells suppressed the osteolineage differentiation of MSCs and disrupted normal hematopoiesis, we comprehensively explored the miRNAs encapsulated in EVs by miRNA-array. Consistent with the heterogeneous nature of MDS, the hypoplastic Abcg2-MDS/AML model and the hyperplastic NHD13Tg model share few elevated miRNAs. However, it is noteworthy that the pathways targeted by each upregulated miRNA are mutually shared, such as the pathways associated with MSC differentiation and survival, including axon guidance and MAPK signaling. These results suggest that miRNAs play an essential role in the MSC impairment observed in MDS.
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Project description:miRNA expression data from HPC-EVs
| PRJNA1030338 | ENA