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A Comparative Transcriptomics Analysis Reveals Ethylene Glycol Derivatives of Squalene Ameliorate Excessive Lipogenesis and Inflammatory Response in 3T3-L1 preadipocytes cells

ABSTRACT: A Comparative Transcriptomics Analysis Reveals Ethylene Glycol Derivatives of Squalene Ameliorate Excessive Lipogenesis and Inflammatory Response in 3T3-L1 preadipocytes cells

PROVIDER: PRJNA929484 | ENA |

REPOSITORIES: ENA

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A Comparative Transcriptomics Analysis Reveals Ethylene Glycol Derivatives of Squalene Ameliorate Excessive Lipogenesis and Inflammatory Response in 3T3-L1 preadipocytes cells

Project description:Transcriptomic analysis reveals the anti-excessive lipogenesis and anti-inflammatory effects of SQ and its derivatives on preadipocyte differentiation We horizontally compared the effects of SQ and its four derivatives on preadipocyte differentiation and anti-inflammation. Di- and tetra-SQ can significantly improve the lipid metabolism function and anti-inflammatory effect of adipocytes, and ameliorate excessive production.

2023-02-18 | GSE224049 | GEO

Ethylene glycol improves electrospray ionization

Project description:We evaluated a number of compounds as LC additives to modify the electrospray response and found that ethylene glycol was capable of enhancing nESI response by a factor of twofold on average. This result was comparable to DMSO.

2017-07-14 | PXD004919 | Pride

Ethylene glycol metabolism in Propionibacterium freudenreichii

Project description:This study was performed to monitor ethylene glycol metabolism by Propionibacterium freudenreichii and to elucidate the metabolic pathway involved.

2024-08-09 | PXD037369 | Pride

Insights on cryoprotectant toxicity from gene expression profiling of endothelial cells exposed to ethylene glycol

Project description:Cryopreservation consists of preserving living cells or tissues at <-100˚C and has many applications in, for instance, stem cell and organ banking. Cryoprotectant agents, like ethylene glycol, are required for successful cryopreservation but have toxic side effects due to largely unknown mechanisms. In this work, we studied the toxicity of ethylene glycol in Human Umbilical Vein Endothelial Cells (HUVECs). Exposing cells to 60% ethylene glycol for two hours at 4˚C resulted in a slight decrease in cell growth, suggesting a modest toxicity of ethylene glycol and that HUVECs do not exhibit particular sensitivity to it. Gene expression analysis with whole genome micro-arrays revealed signatures indicative of a generalized stress response at 24 hours after stress and recovery at 72 hours, involving signaling pathways, glycoproteins, and genes involved in extracellular and transmembrane functions. These results reveal a new paradigm and signatures for future experiments in elucidating the toxicity effects of ethylene glycol in vascular endothelial cells.

2015-11-30 | GSE67511 | GEO

Diethylene Glycol Oligomer Squalene Derivative Improves Hepatic Metabolism and Attenuates Obesity-Related Dysmetabolism via Sirt-AMPK axis Activation

Project description:Diethylene Glycol Oligomer Squalene Derivative Improves Hepatic Metabolism and Attenuates Obesity-Related Dysmetabolism via Sirt-AMPK axis Activation

| PRJNA1183850 | ENA

Bulk RNA of IL-4 and squalene treated MDM

Project description:We performed bulk RNA-seq on squalene/M-CSF-treated macrophages to compute the fold change of genes in the squalene/M-CSF compared to M-CSF alone treated macrophages. We then looked at the distribution of the log fold changes in the skin-derived TREM2 (607 genes) and M2-like (709 genes) macrophage scRNA-seq signatures. We found that the TREM2 gene signature was more highly induced by squalene/M-CSF than the M2-like macrophage signature. In these squalene-induced macrophages, we found upregulation of several of the lipid metabolism and pro-inflammatory genes present in the skin-derived TREM2 macrophage gene signature.

2021-11-09 | GSE188363 | GEO

Hepatic transcriptomics of squalene in male Apoe-deficient mice on Western diet

Project description:Background and Purpose: Squalene is the main hydrocarbon present in extra virgin olive oil and it has been reported to have anti-steatotic properties in different animal models. The aims of this study were to investigate its effects on liver transcriptomics in Male C57BL/6J Apoe-deficient mice. Experimental Approaches: Male C57BL/6J Apoe-deficient mice were fed a purified Western diet with or without squalene during 11 weeks and hepatic squalene content was assessed. Hepatic transcriptomic changes were studied and confirmed by RT-qPCR. Key Results: Squalene supplementation increased its hepatic content. The Cyp2b10 and Cyp2c55 gene expressions were significantly up-regulated by the squalene intake in all animal models, with independence of sex, sexual hormones, dietary fat content, genetic background and dose, and were strongly associated with antioxidant defense capacity and with lipid content and composition. Conclusions and Implications: hepatic squalene exerts its activity through overexpression of these cytochromes and their changes in virgin olive oil diets may be due to squalene.

2021-04-30 | GSE145343 | GEO

Effect of squalene on liver transcriptome of mice lacking apolipoprotein E

2016-03-30 | GSE36932 | GEO

Effect of squalene on liver transcriptome of mice lacking apolipoprotein E

Project description:The hypothesis that the squalene of olive oil might influence hepatic gene expression in an apoE and sex-dependent ways was tested in mice. Gene expression was analyzed using DNA microarrays in male apoE-deficient mice that received 1 g/kg/day of squalene for 10 weeks. As initial screening of potential candidate genes involved in a differential response, only genes with remarkably modified expression (signal log2 ratio > 1.5 or < -1.5) were further considered

2016-03-30 | E-GEOD-36932 | biostudies-arrayexpress

RNA-seq of Staphylococcus aureus and Staphylococcus aureus challenged with squalene compared to control growth

Project description:Squalene makes up 12 % of human skin surface lipids, however little is known about its affects on the host skin microbiome. Here we tested the effect of squalene on genetic regulation of staphylococci, showing that it profoundly affects expression virulence or colonisation determinants, and of iron uptake systems.

2018-06-30 | E-MTAB-6352 | biostudies-arrayexpress

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