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Limosilactobacillus vaginalis

ABSTRACT: Complete Genome Sequences of Limosilactobacillus vaginalis and Limosilactobacillus portuensis Strains Isolated from the Urine of Postmenopausal Women

PROVIDER: PRJNA930673 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
		Other
	SRR25546979_1.fastq.gz	Fastqsanger.gz
	SRR25546980_1.fastq.gz	Fastqsanger.gz
	SRR25546980_2.fastq.gz	Fastqsanger.gz
	SRR25546981_1.fastq.gz	Fastqsanger.gz

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Limosilactobacillus vaginalis

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Gardnerella vaginalis activates host responses necessary for Escherichia coli recurrent UTI from bladder reservoirs

Project description:Recurrent urinary tract infections (rUTI) are a costly clinical problem affecting millions of women worldwide each year. The majority of rUTI cases are caused by uropathogenic Escherichia coli (UPEC). Data from humans and mouse models indicate that some instances of rUTI are caused by UPEC emerging from latent reservoirs in the bladder. Some studies have reported that women with vaginal dysbiosis, typically characterized by high levels of Gardnerella vaginalis and other anaerobes, are at increased risk of UTI. Multiple studies have detected G. vaginalis in urine collected by transurethral catheterization (to limit vaginal contamination), suggesting that some women experience routine urinary tract exposures. We recently reported that inoculation of G. vaginalis into the bladder triggers rUTI from UPEC bladder reservoirs in a mouse model. Here we performed whole bladder RNAseq to identify host pathways involved in G. vaginalis-induced rUTI. We identified multiple host pathways differentially expressed following G. vaginalis exposure. At the gene and transcript level, we identified upregulation of the orphan nuclear receptor Nur77 (aka Nr4a1) and Nur77-regulated genes. Pilot data from Nur77 knockout mice suggests that Nur77 is necessary for G. vaganalis exposure to trigger rUTI.

2021-11-01 | GSE186800 | GEO

Limosilactobacillus vaginalis strain:GSH01

Project description:Limosilactobacillus vaginalis strain:GSH01 Genome sequencing

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Limosilactobacillus vaginalis strain:AM_LB9

Project description:Limosilactobacillus vaginalis strain:AM_LB9 Genome sequencing

| PRJNA880306 | ENA

Limosilactobacillus vaginalis strain:VAG1

Project description:Limosilactobacillus vaginalis VAG1 (Genome sequencing and assembly)

| PRJNA784112 | ENA

Limosilactobacillus vaginalis strain:BC17

Project description:Limosilactobacillus vaginalis strain BC17 Genome sequencing and assembly

| PRJNA933554 | ENA

Limosilactobacillus vaginalis

Project description:Lactobacillus vaginalis overview

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Limosilactobacillus vaginalis strain:CBA-L88 (BV2)

Project description:Limosilactobacillus vaginalis strain:CBA-L88 (BV2) Genome sequencing and assembly

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Project description:Complete Genome Sequences of Lactobacillus spp. Isolated from the Urine of Postmenopausal Women

| PRJNA761982 | ENA

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