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ID3 defines T cells with stem-like potential and sustains their response to chronic infection

ABSTRACT: ID3 defines T cells with stem-like potential and sustains their response to chronic infection

PROVIDER: PRJNA930729 | ENA |

REPOSITORIES: ENA

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ID3 defines T cells with stem-like potential and sustains their response to chronic infection

Project description:Memory CD8+ T cells and precursors of exhausted T (Tpex) cells are important therapeutic targets due to their stem-like potential that allows them to self-renew while also giving rise to large numbers of effector T cells that can provide protection from infection or uncontrolled tumor growth. Identifying T cells with stem-like potential and understanding their molecular regulation is therefore critical to improve a wide range of T cell-focused therapies ranging from vaccination to checkpoint inhibitor and chimeric antigen receptor T cell therapies. Here, we identify memory T cells based on expression of the transcriptional regulator ID3 while lacking expression of the chemokine receptor CXCR6 with superior stem-like potential to sustain T cell responses during chronic infection. Mechanistically, ID3 regulated a transcriptional network including Myb, Sell and cKit that promoted T cell stemness that was specifically required during ongoing T cell receptor stimulation. T cells lacking ID3 were unable to sustain a long-term response to chronic infection but capable of efficiently responding to acute infection. Overall, we identify a critical role for ID3 in promoting functional and long-lasting T cell responses specifically to chronic infections and highlight ID3-expressing stem-like memory T cells as a promising immunotherapeutic target to improve immune responses in chronic infections or tumors.

2024-12-14 | GSE224367 | GEO

ID3 and c-Kit define the stem-like potential of T cells and their response to chronic infection and cancer

2024-12-13 | GSE226030 | GEO

Stem-like potential of T cells in infection and cancer is regulated by ID3

2024-12-13 | GSE277451 | GEO

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

Project description:This SuperSeries is composed of the following subset Series: GSE36346: The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (ChIP-Seq data) GSE36347: The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (expression data) Refer to individual Series

2012-03-28 | E-GEOD-36348 | biostudies-arrayexpress

Dynamic expression of Id3 defines the stepwise differentiation of tissue-resident regulatory T cells

Project description:Foxp3+ regulatory T (TR) cells are phenotypically and functionally diverse, and broadly distributed in lymphoid and non-lymphoid tissues. However, the pathways guiding the differentiation of tissue-resident TR populations have not been well defined. By regulating E-protein function, Id3 controls the differentiation of CD8+ effector T cells and is essential for TR maintenance and function. We show that dynamic expression of Id3 helps define three distinct mouse TR populations, Id3+CD62LhiCD44lo central (c)TR, Id3+CD62LloCD44hi effector (e)TR and Id3- eTR. Adoptive transfer experiments and transcriptome analyses support a stepwise model of differentiation from Id3+ cTR to Id3+ eTR to Id3- eTR. Furthermore, Id3- eTR have high expression of functional inhibitory markers and a transcriptional signature of tissue-resident TR. Accordingly, Id3- eTR are highly enriched in non-lymphoid organs, but virtually absent from blood and lymph. Thus, we propose that tissue-resident TR develop in a multi-step process associated with Id3 downregulation.

2018-11-16 | GSE122593 | GEO

Expression data from sorted Id3-GFP hi Id2-YFP int and Id3-GFP lo Id2-YFP hi activated CD8 T cells

Project description:During an immune response, CD8 T cells fall along a gradient of memory potential, but the regulators of these fate decsisions are not well understood. We utlized Id3-GFP and Id2-YFP reporter mice to elucidate the role of Id3 and Id2 during early CD8 T cell differentiation by gene expression. Id3-GFP hi Id2-YFP int or Id3-GFP lo Id2-YFP hi OT-I cells were sorted into trizol at day 6 of VSV-OVA infection and analyzed by microarray

2011-10-06 | E-GEOD-32675 | biostudies-arrayexpress

ID3 and c-Kit define the stem-like potential of T cells and their response to chronic infection and cancer

Project description:ID3 and c-Kit define the stem-like potential of T cells and their response to chronic infection and cancer

| PRJNA938396 | ENA

Dynamic expression of Id3 defines the stepwise differentiation of tissue-resident regulatory T cells

Project description:Dynamic expression of Id3 defines the stepwise differentiation of tissue-resident regulatory T cells

| PRJNA505690 | ENA

Expression data from sorted Id3-GFP hi Id2-YFP int and Id3-GFP lo Id2-YFP hi activated CD8 T cells

2011-10-07 | GSE32675 | GEO

LSM12-EPAC1 Defines a Neuroprotective Pathway that Sustains the Nucleocytoplasmic RAN Gradient

Project description:LSM12-EPAC1 Defines a Neuroprotective Pathway that Sustains the Nucleocytoplasmic RAN Gradient

| PRJNA672153 | ENA