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Transcriptome profiling of NCI-H2030 cell line treated with adagrasib, K-975 and adagrasib+K-975

ABSTRACT: Transcriptome profiling of NCI-H2030 cell line treated with adagrasib, K-975 and adagrasib+K-975

PROVIDER: PRJNA931250 | ENA |

REPOSITORIES: ENA

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Transcriptome profiling of NCI-H2030 cell line treated with adagrasib, K-975 and adagrasib+K-975

Project description:NCI-H2030 lines were seeded in 6-well plates in complete culture medium and cultured at densities allowing exponential growth: 50000 cells/well. After 24 h, compounds were added (DMOS, adagrasib (30 nM), K-975 (100 nM) and adagrasib (30 nM)+K-975 (100 nM)) at a final percentage of 0.2% DMSO. Twenty-four hours after compounds addition, cells were used for transcriptomic profiling.

2023-02-09 | GSE224439 | GEO

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Transcriptome profiling of Anlotinib-resistant NCI-H1975 and Anlotinib-treated Anlotinib-resistant NCI-H1975

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Human malignant mesothelioma NCI-H226 cells treated with TEAD inhibitor K-975 in SCID mice.

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NCI-H716 cell line treated with Akkermansia muciniphila secerted protein P9

Project description:NCI-H716 cell line treated with Akkermansia muciniphila secerted protein P9

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Transcriptome sequencing of human lung cancer cell line NCI-H838 treated with LINC00472 overexpression

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Gene expression data from NCI-H295R cell line treated with rottlerin samples.

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Evaluation of NCI-7 Cell Line Panel

Project description:Reference materials are vital to benchmarking the reproducibility of clinical tests and essential for monitoring laboratory performance for clinical proteomics. The reference material utilized for mass spectrometric analysis of the human proteome would ideally contain enough proteins to be suitably representative of the human proteome, as well as exhibit a stable protein composition in different batches of sample regeneration. Previously, The Clinical Proteomic Tumor Analysis Consortium (CPTAC) utilized PDX-derived comparative reference (CompRef) materials for the longitudinal assessment of proteomic performance, however, inherent drawbacks of PDX-derived material has resulted in efforts to identify a new source of CompRef material. In this study, we examined the utility of using a panel of seven cancer cell lines, NCI-7 Cell Line Panel, as a reference material for mass spectrometric analysis of the human proteome. Our results showed that not only is the NCI-7 material suitable for benchmarking laboratory sample preparation methods, but NCI-7 sample generation is highly reproducible at both the global and phosphoprotein levels. In addition, the predicted genomic and experimental coverage of the NCI-7 proteome suggests the NCI-7 material may also have applications as a universal standard proteomic reference.

2018-05-14 | PXD008952 | Pride

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