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DNA methylation changes in mice induced by parabiosis and recovery [RRBS]

ABSTRACT: DNA methylation changes in mice induced by parabiosis and recovery [RRBS]

PROVIDER: PRJNA931268 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23332105_1.fastq.gz	Fastqsanger.gz
	SRR23332105_2.fastq.gz	Fastqsanger.gz
	SRR23332106_1.fastq.gz	Fastqsanger.gz
	SRR23332106_2.fastq.gz	Fastqsanger.gz
	SRR23332107_1.fastq.gz	Fastqsanger.gz

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DNA methylation changes in mice induced by parabiosis and recovery [RRBS]

Project description:Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age is perturbed. Heterochronic parabiosis and recovery from this procedure is one such example.

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DNA methylation changes in mice induced by parabiosis and recovery [HorvathMammalMethylChip40]

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DNA methylation and gene expression changes in mice induced by parabiosis and recovery

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Project description:Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age, assessed primarily through analysis of DNA methylation, undergoes reversible changes. Heterochronic parabiosis is one such example.

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DNA methylation and gene expression changes in mice induced by parabiosis and recovery

Project description:This SuperSeries is composed of the SubSeries listed below.

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Extensive changes in DNA methylation are associated with expression of mutant huntingtin [RRBS]

Project description:The earliest stages of Huntington’s disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin protein (HTT). To explore the hypothesis DNA methylation may be altered in cells expressing mutated HTT, we use reduced-representation bisulfite sequencing (RRBS) to map sites of DNA methylation in cells carrying either wild-type or mutant HTT. We find that a large fraction of the genes that change in expression in the presence of mutant huntingtin demonstrate significant changes in DNA methylation. Regions with low CpG content, which have previously been shown to undergo methylation changes in response to neuronal activity, are disproportionately affected. Based on the sequence of regions that change in methylation, we identify AP-1 and SOX2 as transcriptional regulators associated with DNA methylation changes, and we confirm these hypotheses using genome-wide chromatin immunoprecipitation (ChIP-Seq). Our findings suggest new mechanisms for the effects of polyglutamine-expanded HTT. These results also raise important questions about the potential effects of changes in DNA methylation on neurogenesis and at later stages, cognitive decline in Huntington’s patients. RRBS in STHdhQ7/Q7 and STHdhQ111/Q111 cells

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