Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression profile of primary murine astrocyte-enriched cultures (AEC) exposed to oxygen-glucose deprivation

ABSTRACT: Expression profile of primary murine astrocyte-enriched cultures (AEC) exposed to oxygen-glucose deprivation

PROVIDER: PRJNA931909 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Expression profile of primary murine astrocyte-enriched cultures (AEC) exposed to oxygen-glucose deprivation

Project description:Microarray analysis was used to identify genes that fluctuated by oxygen-glucose deprivation of mouse astrocytes. Astrocyte-enriched cultures were generated from mixed glial cultures of mice and compared to control samples with 15 hours of oxygen-glucose deprivation. The results showed that 173 genes were upregulated with Fold change >10, P < 0.05. Both Nr4a1 and Nr4a3, which is an orphan nuclear receptor subfamily and known as an immediate early gene, were upregulated.

2023-02-11 | GSE224577 | GEO

miRNA profile of microglial cells under oxygen-glucose deprivation

2015-11-23 | GSE63504 | GEO

Transcriptome analysis of influenza infected GFP+ AEC compared to bystander GFP- AEC

Project description:A GFP-expressing recombinant A/Puerto Rico/8/1934 influenza virus was used to infect C57BL/6 wild type mice and on day 3 post infection, lung alveolar epithelial cells (AEC) were isolated and sorted based on GFP expression. GFP+ AEC represent the infected AEC and GFP- AEC represent the bystander AEC. AEC were also sorted from uninfected mice to serve as controls.

2018-08-29 | GSE119123 | GEO

Gene expression profile of microglial cells under oxygen-glucose deprivation

Project description:Migroglia cells were exposed to oxygen-glucose deprivation (OGD) for 3 h. The mRNA was isolated and the expression profiles of OGD-activated cells were compared with the profiles of resting cells.

2015-11-23 | GSE63505 | GEO

miRNA profile of microglial cells under oxygen-glucose deprivation

Project description:Migroglia cells were exposed to oxygen-glucose deprivation (OGD) for 3 h. The miRNA was isolated and the expression profiles of OGD-activated cells were compared with the profiles of resting cells. Two samples were analysed. miRNAs that were differentially expressed (increased or decreased in expression by â¥1.5-fold) between theOGD-activated and resting cells were identified.

2015-11-23 | E-GEOD-63504 | biostudies-arrayexpress

Expression data from human astrocytes (HA) under oxygen-glucose deprivation / reoxygenation

Project description:Ischemia lead to neuronal injury. Dexmedetomidine and astrocytes are likely to protect neuronal cells against ischemia-induced injury. We used microarrays to examine the gene expression variation in astrocytes activated by oxygen-glucose deprivation and reoxygenation stress and identified distinct classes of genes up- and down-regulated by dexmedetomidine pretreatment.

2021-02-05 | GSE166193 | GEO

Global transcriptomic profiling of oxygen-glucose deprivation (OGD)-mediated neuronal injury

Project description:Oxygen-glucose deprivation (OGD) is a cellular phenomenon consistently observed upon occurrence of ischemic stroke which eventually results in neuronal death. Neuronal cell death after ischemia takes place via two distinct processes, necrosis and apoptosis. Apoptosis, programmed cell death, is denoted by chromatin condensation, nuclear blebbing, cellular shrinkage, and DNA fragmentation. Unlike apoptosis, cellular swelling and lysis is suggestive of necrosis. However, these two processes are related not only to the severity but also to the duration of ischemia.

2013-12-31 | GSE23158 | GEO

Disrupted transcripitonal network in ΔNp63 AEC tissue model [gene expression]

Project description:The transcriptional basis for disrupted epidermal differentiation arising from TP63 AEC mutations remains to be elucidated. Here we present an organotypic model of AEC dysfunction that phenocopies differentiation defects observed in AEC patient skin. Transcriptional analysis of model AEC tissue revealed impaired induction of differentiation regulators, including OVOL1, GRHL3, KLF4, PRDM1 and ZNF750. Genome wide binding analyses of TP63 during epidermal differentiation showed direct binding of OVOL1, GRHL3, and ZNF750 promoters suggesting AEC mutants prevent normal activation of these targets by direct transcriptional interference. Remarkably, exogenous ZNF750 restores impaired epidermal differentiation caused by AEC mutation. Thus, repression of ZNF750 is central to disrupted epidermal differentiation in model AEC tissue.

2012-06-18 | GSE33495 | GEO

Disrupted transcriptional network in ΔNp63 AEC tissue model [ChIP-Seq]

2012-06-18 | GSE33571 | GEO

Disrupted transcripitonal network in ΔNp63 AEC tissue model [gene expression]

2012-06-17 | E-GEOD-33495 | biostudies-arrayexpress